{"id":10577,"date":"2022-04-07T10:41:55","date_gmt":"2022-04-07T02:41:55","guid":{"rendered":"https:\/\/cde.nus.edu.sg\/cee\/?page_id=10577"},"modified":"2022-10-03T12:22:06","modified_gmt":"2022-10-03T04:22:06","slug":"microbial-detoxification-of-persistent-organohalide-pollutants-pops","status":"publish","type":"page","link":"https:\/\/cde.nus.edu.sg\/cee\/research\/research-clusters\/environmental-sustainability\/microbial-detoxification-of-persistent-organohalide-pollutants-pops\/","title":{"rendered":"Microbial detoxification of persistent organohalide pollutants (POPs)"},"content":{"rendered":"\n\n\t\t\t\t\t<ul id=\"menu-research\"><li id=\"menu-item-13844\"><a href=\"https:\/\/cde.nus.edu.sg\/cee\/research\/research-clusters\/\">Research Clusters<\/a>\n<ul>\n\t<li id=\"menu-item-13848\"><a href=\"https:\/\/cde.nus.edu.sg\/cee\/research\/research-clusters\/built-environment\/\">Built Environment 4.0<\/a>\n\t<ul>\n\t\t<li id=\"menu-item-14104\"><a href=\"https:\/\/cde.nus.edu.sg\/cee\/research\/research-clusters\/built-environment\/autonomous-bim-ready-drone-system-for-building-facades-inspection\/\">Autonomous BIM-ready Drone System for Building Facades Inspection<\/a><\/li>\n\t\t<li id=\"menu-item-14105\"><a href=\"https:\/\/cde.nus.edu.sg\/cee\/research\/research-clusters\/built-environment\/intelligent-lifting-frame-for-ppvc-and-precast-construction\/\">Intelligent Lifting Frame for PPVC and Precast Construction<\/a><\/li>\n\t\t<li id=\"menu-item-14106\"><a href=\"https:\/\/cde.nus.edu.sg\/cee\/research\/research-clusters\/built-environment\/lightweight-high-strength-steel-concrete-composite-modular-buildings-with-fast-track-connections\/\">Lightweight High-Strength Steel-Concrete Composite Modular Buildings with Fast Track Connections<\/a><\/li>\n\t<\/ul>\n<\/li>\n\t<li id=\"menu-item-13847\"><a href=\"https:\/\/cde.nus.edu.sg\/cee\/research\/research-clusters\/ccm\/\">Climate Change Mitigation<\/a>\n\t<ul>\n\t\t<li id=\"menu-item-14111\"><a href=\"https:\/\/cde.nus.edu.sg\/cee\/research\/research-clusters\/ccm\/bridging-scales-from-below\/\">Bridging Scales from Below: The Role of Heterogeneities in the Global Water and Carbon Budgets<\/a><\/li>\n\t\t<li id=\"menu-item-14108\"><a href=\"https:\/\/cde.nus.edu.sg\/cee\/research\/research-clusters\/ccm\/increasing-occurrences-of-cyanobacterial-blooms-driven-by-climate-change-factors\/\">Increasing Occurrences of Cyanobacterial Blooms Driven by Climate Change Factors<\/a><\/li>\n\t\t<li id=\"menu-item-14107\"><a href=\"https:\/\/cde.nus.edu.sg\/cee\/research\/research-clusters\/ccm\/carbon-capture-and-utilization\/\">Carbon Capture and Utilization<\/a><\/li>\n\t\t<li id=\"menu-item-14109\"><a href=\"https:\/\/cde.nus.edu.sg\/cee\/research\/research-clusters\/ccm\/integrated-coastal-inland-flood-model-for-climate-change\/\">Integrated Coastal-Inland Flood Model for Climate Change<\/a><\/li>\n\t\t<li id=\"menu-item-14110\"><a href=\"https:\/\/cde.nus.edu.sg\/cee\/research\/research-clusters\/ccm\/pathways-for-sustainable-and-climate-resilient-planning-of-water-energy-food-security-nexus\/\">Pathways for Sustainable and Climate-Resilient Planning of Water-Energy-Food Security Nexus<\/a><\/li>\n\t<\/ul>\n<\/li>\n\t<li id=\"menu-item-13846\"><a href=\"https:\/\/cde.nus.edu.sg\/cee\/research\/research-clusters\/environmental-sustainability\/\">Environmental Sustainability<\/a>\n\t<ul>\n\t\t<li id=\"menu-item-14113\"><a href=\"https:\/\/cde.nus.edu.sg\/cee\/research\/research-clusters\/environmental-sustainability\/air-quality-and-health-a-paradigm-shift\/\">Air Quality and Health: A Paradigm Shift<\/a><\/li>\n\t\t<li id=\"menu-item-14114\"><a href=\"https:\/\/cde.nus.edu.sg\/cee\/research\/research-clusters\/environmental-sustainability\/surface-water-quality-and-emerging-contaminants\/\">Surface Water Quality and Emerging Contaminants<\/a><\/li>\n\t\t<li id=\"menu-item-14115\"><a href=\"https:\/\/cde.nus.edu.sg\/cee\/research\/research-clusters\/environmental-sustainability\/microbial-detoxification-of-persistent-organohalide-pollutants-pops\/\">Microbial detoxification of persistent organohalide pollutants (POPs)<\/a><\/li>\n\t\t<li id=\"menu-item-14116\"><a href=\"https:\/\/cde.nus.edu.sg\/cee\/research\/research-clusters\/environmental-sustainability\/nutrients-removal-in-waterbodies-via-sustainable-pathways\/\">Nutrients Removal in Waterbodies via Sustainable Pathways<\/a><\/li>\n\t\t<li id=\"menu-item-14117\"><a href=\"https:\/\/cde.nus.edu.sg\/cee\/research\/research-clusters\/environmental-sustainability\/centre-for-water-research-cwr-researchers-join-their-forces-with-u-of-t-researchers-for-microplastics-pollution-detection-and-control-in-water-and-wastewater\/\">Centre for Water Research (CWR) researchers join their forces with U of T researchers for microplastics pollution detection and control in water and wastewater<\/a><\/li>\n\t<\/ul>\n<\/li>\n\t<li id=\"menu-item-13845\"><a href=\"https:\/\/cde.nus.edu.sg\/cee\/research\/research-clusters\/ocean-infrastructure-and-renewables\/\">Ocean Infrastructure and Renewables<\/a>\n\t<ul>\n\t\t<li id=\"menu-item-14118\"><a href=\"https:\/\/cde.nus.edu.sg\/cee\/research\/research-clusters\/ocean-infrastructure-and-renewables\/\">Ocean Infrastructure and Renewables<\/a><\/li>\n\t\t<li id=\"menu-item-14119\"><a href=\"https:\/\/cde.nus.edu.sg\/cee\/research\/research-clusters\/ocean-infrastructure-and-renewables\/evaluation-of-in-situ-consolidation-of-dredged-and-excavated-materials-at-the-reclaimed-next-generation-tuas-port\/\">Evaluation of In-Situ Consolidation of Dredged and Excavated Materials at the Reclaimed Next Generation Tuas Port<\/a><\/li>\n\t\t<li id=\"menu-item-14120\"><a href=\"https:\/\/cde.nus.edu.sg\/cee\/research\/research-clusters\/ocean-infrastructure-and-renewables\/enhancing-offshore-system-productivity-integrity-and-survivability-in-extreme-environments-wp2-local-digital-twin\/\">Enhancing Offshore System Productivity, Integrity and Survivability in Extreme Environments &#8211; WP2: Local Digital Twin<\/a><\/li>\n\t<\/ul>\n<\/li>\n\t<li id=\"menu-item-13843\"><a href=\"https:\/\/cde.nus.edu.sg\/cee\/research\/research-clusters\/resilient-infrastructures\/\">Resilient Infrastructures<\/a>\n\t<ul>\n\t\t<li id=\"menu-item-14121\"><a href=\"https:\/\/cde.nus.edu.sg\/cee\/research\/research-clusters\/resilient-infrastructures\/digital-fabrication-of-concrete-for-sustainable-and-resilient-built-environment\/\">Digital Fabrication of Concrete for Sustainable and Resilient Built Environment<\/a><\/li>\n\t\t<li id=\"menu-item-14122\"><a href=\"https:\/\/cde.nus.edu.sg\/cee\/research\/research-clusters\/resilient-infrastructures\/upcycling-local-waste-for-sustainable-concreting-in-marine-conditions\/\">Upcycling Local Waste for Sustainable Concreting in Marine Conditions<\/a><\/li>\n\t\t<li id=\"menu-item-14123\"><a href=\"https:\/\/cde.nus.edu.sg\/cee\/research\/research-clusters\/resilient-infrastructures\/development-of-sustainable-self-healing-concrete-by-use-of-recycled-materials\/\">Development of Sustainable Self-Healing Concrete by Use of Recycled Materials<\/a><\/li>\n\t\t<li id=\"menu-item-14124\"><a href=\"https:\/\/cde.nus.edu.sg\/cee\/research\/research-clusters\/resilient-infrastructures\/low-carbon-construction-materials-incorporating-solid-waste\/\">Low-carbon Construction Materials Incorporating Solid Waste<\/a><\/li>\n\t<\/ul>\n<\/li>\n\t<li id=\"menu-item-13842\"><a href=\"https:\/\/cde.nus.edu.sg\/cee\/research\/research-clusters\/slc\/\">Smart and Liveable Cities<\/a>\n\t<ul>\n\t\t<li id=\"menu-item-14125\"><a href=\"https:\/\/cde.nus.edu.sg\/cee\/research\/research-clusters\/slc\/intelligent-traffic-diffusion-plan-generation-effective-assessment-and-dissemination-strategies\/\">Intelligent Traffic Diffusion Plan Generation, Effective Assessment and Dissemination Strategies<\/a><\/li>\n\t\t<li id=\"menu-item-14126\"><a href=\"https:\/\/cde.nus.edu.sg\/cee\/research\/research-clusters\/slc\/transforming-waste-into-resources-for-infrastructural-development\/\">Transforming Waste into Resources for Infrastructural Development<\/a><\/li>\n\t\t<li id=\"menu-item-14127\"><a href=\"https:\/\/cde.nus.edu.sg\/cee\/research\/research-clusters\/slc\/look-ahead-integrated-geophysical-investigation-system-igis-for-singapore-tunnels\/\">Look-Ahead Integrated Geophysical Investigation System (IGIS) for Singapore Tunnels<\/a><\/li>\n\t\t<li id=\"menu-item-14128\"><a href=\"https:\/\/cde.nus.edu.sg\/cee\/research\/research-clusters\/slc\/next-generation-airport-pavements-with-full-scale-instrumented-testing\/\">Next-Generation Airport Pavements with Full-Scale Instrumented Testing<\/a><\/li>\n\t<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<li id=\"menu-item-13849\"><a href=\"https:\/\/cde.nus.edu.sg\/cee\/research\/research-centres\/\">Research Centres<\/a>\n<ul>\n\t<li id=\"menu-item-14131\"><a href=\"https:\/\/cde.nus.edu.sg\/cee\/research\/research-centres\/centre-for-advanced-materials-and-structures\/\">Centre for Advanced Materials and Structures<\/a><\/li>\n\t<li id=\"menu-item-14132\"><a href=\"https:\/\/cde.nus.edu.sg\/cee\/research\/research-centres\/centre-for-hazard-research\/\">Centre for Hazard Research<\/a><\/li>\n\t<li id=\"menu-item-14130\"><a href=\"https:\/\/cde.nus.edu.sg\/cee\/research\/research-centres\/centre-for-soft-ground-engineering\/\">Centre for Soft Ground Engineering<\/a><\/li>\n\t<li id=\"menu-item-14129\"><a 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href=\"https:\/\/cde.nus.edu.sg\/cee\/research\/laboratories\/highway-engineering-laboratory\/\">Highway Engineering Laboratory<\/a><\/li>\n\t<li id=\"menu-item-14134\"><a href=\"https:\/\/cde.nus.edu.sg\/cee\/research\/laboratories\/geotechnical-engineering-laboratory\/\">Geotechnical Engineering Laboratory<\/a><\/li>\n\t<li id=\"menu-item-14133\"><a href=\"https:\/\/cde.nus.edu.sg\/cee\/research\/laboratories\/environmental-engineering-laboratory\/\">Environmental Engineering Laboratory<\/a><\/li>\n<\/ul>\n<\/li>\n<li id=\"menu-item-13854\"><a href=\"https:\/\/cde.nus.edu.sg\/cee\/graduate\/graduate-research\/safety-health-committee\/\">Safety &amp; Health Committee<\/a><\/li>\n<li id=\"menu-item-13855\"><a href=\"https:\/\/cde.nus.edu.sg\/cee\/graduate\/graduate-research\/completed-research-projects\/\">Completed Research Projects<\/a><\/li>\n<li id=\"menu-item-13856\"><a href=\"https:\/\/cde.nus.edu.sg\/cee\/research\/research-brief\/\">Research Brief<\/a><\/li>\n<li id=\"menu-item-13857\"><a href=\"https:\/\/cde.nus.edu.sg\/cee\/research\/achievements-in-the-media\/\">Achievements (in the media)<\/a><\/li>\n<\/ul>\t\n\t<h2>\n\t\tMicrobial detoxification of persistent organohalide pollutants (POPs)\n\t<\/h2>\n\t<p><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/cde.nus.edu.sg\/wp-content\/uploads\/sites\/7\/2022\/04\/Microbial-Detoxification-of-Persistent-Fig1--1024x366.png\" alt=\"Microbial Detoxification Of Persistent Fig1\" width=\"650\" height=\"232\" \/><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/cde.nus.edu.sg\/wp-content\/uploads\/sites\/7\/2022\/04\/Microbial-Detoxification-of-Persistent-Fig2-300x262.png\" alt=\"Microbial Detoxification Of Persistent Fig2\" width=\"300\" height=\"262\" \/><\/p>\n<p>Persistent organohalide pollutants (POPs) are widely used in industrial and agricultural areas. The inappropriate disposal of these pollutants results in severe contamination in surface water, groundwater, soils and sediments. Long term exposure to organohalide pollutants has been linked to human diseases in liver, kidneys, reproductive, nervous and immune systems.\u00a0 The goal of our projects is to cultivate and characterize cultures capable of detoxify these pollutants in tandem with state of the art -omics tools to provide a sustainable and economical solutions to POPs contamination.&#8217;<\/p>\n<p>Anaerobic bacteria play a critical role in bioremediation of halogenated compounds in the environment. Novel bacteria are characterized to be capable of dehalogenating polychlorinated biphenyl (PCBs), polybrominated diphenyl ether (PBDEs), and chlorinated solvents. \u00a0Employing a combination of traditional culturing techniques and -omics technology, we identified an array of unique functional reductive dehalogenase genes, a significant advancement towards the ultimate goal of <em>in situ<\/em> remediation of POPs and chlorinated solvents. Furthermore, characterization of the functional reductive dehalogenase homologous (<em>rdh<\/em>) genes can be serve as an advanced monitoring markers to infer bioremediation potential and monitoring dehalogenation activity at contaminated sites, especially following augmentation of the novel strains (image 1-3).\u00a0<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/cde.nus.edu.sg\/wp-content\/uploads\/sites\/7\/2022\/04\/Microbial-Detoxification-of-Persistent-Fig3-1024x709.png\" alt=\"Microbial Detoxification Of Persistent Fig3\" width=\"597\" height=\"414\" \/><\/p>\n<p><em>Image 1: Debromination of tetra- and penta-BDE congeners by D.mccartyi strains GY50 (A); dechlorination of Aroclor 1260 by D.mccartyi strains CG1, CG4 and CG5 (B).<\/em><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/cde.nus.edu.sg\/wp-content\/uploads\/sites\/7\/2022\/04\/Microbial-Detoxification-of-Persistent-Fig4.png\" alt=\"Microbial Detoxification Of Persistent Fig4\" width=\"483\" height=\"182\" \/><\/p>\n<p><em>Image 2: Graphical scheme for scaling up the dehalogenating cultures<\/em><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/cde.nus.edu.sg\/wp-content\/uploads\/sites\/7\/2022\/04\/Microbial-Detoxification-of-Persistent-Fig5.png\" alt=\"Microbial Detoxification Of Persistent Fig5\" width=\"682\" height=\"233\" \/><\/p>\n<p><em>Image 3: Dechlorination of TCA and chloroform by Desulfitobacterium sp. strain PR<\/em><strong><\/strong><\/p>\n<p><\/p>\n<p>For more details, please contact:<br \/><a href=\"https:\/\/cde.nus.edu.sg\/cee\/staff\/he-jianzhong\/\" target=\"_blank\" rel=\"noopener\"><strong>Prof He Jianzhong<\/strong><\/a><br \/>Email: <a href=\"mailto:ceehj@nus.edu.sg\">ceehj@nus.edu.sg<\/a><\/p>\n\n","protected":false},"excerpt":{"rendered":"<p>Research Clusters Built Environment 4.0 Autonomous BIM-ready Drone System for Building Facades Inspection Intelligent Lifting Frame for PPVC and Precast Construction Lightweight High-Strength Steel-Concrete Composite Modular Buildings with Fast Track Connections Climate Change Mitigation Bridging Scales from Below: The Role of Heterogeneities in the Global Water and Carbon Budgets Increasing Occurrences of Cyanobacterial Blooms Driven [&hellip;]<\/p>\n","protected":false},"author":54,"featured_media":9438,"parent":10516,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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