Lohxj

LOH Xian Jun

Adjunct Professor

MSE

Research Interests

My research interest is primarily in the area of soft materials. Soft materials have been known include hydrogels, organogels, micelles, vesicles and many others. The underlying theme of my research covers the following: 1) modification of naturally available biodegradable polymers for the synthesis of soft materials; 2) characterization of the soft materials properties and 3) development of simple fabrication techniques to realising these soft material constructs. I am particularly interested in exploring topics such as water-soluble and stimuli-responsive soft materials for drug/gene/protein delivery and tissue engineering/repair applications. My industrial interests are intricately linked with my role as A*STAR’s Personal Care Programme Manager. I am interested in developing personal, household, medical and baby care products.

Book

Polymeric and Self Assembled Hydrogels: From Fundamental Understanding to Applications, Xian Jun Loh (Editor), Oren A. Scherman (Editor)

ISBN:978-1-84973-561-2, Publisher:Royal Society of Chemistry

Link: http://www.rsc.org/shop/books/2012/9781849735612.asp

Selected Publications:

Biodegradable polymers and their applications

  1. X.J. Loh, K.K. Tan, X. Li, J. Li “The in vitro hydrolysis of poly(ester urethane)s consisting of poly[(R)-3-hydroxybutyrate] and poly(ethylene glycol)”, Biomaterials, 27, 2006, 1841-1850
  2. X.J. Loh, X. Wang, H.Z. Li, X. Li, J. Li “Compositional study and cytotoxicity of biodegradable poly(ester urethane)s consisting of poly [(R)-3-hydroxybutyrate] and poly(ethylene glycol)”, Materials Science and Engineering C, 27, 2007, 267-273
  3. X. J. Loh, K.B.C. Sng, J. Li, “Synthesis and water-swelling of thermo-responsive poly(ester urethane)s containing polycaprolactone, poly(ethylene glycol) and poly(propylene glycol).” Biomaterials, 29, 2008, 3185-3194.
  4. X. J. Loh, Y. L. Wu, W. T. J. Seow, M. N. I. Norimzan, Z. X. Zhang, F. J. Xu, E. T. Kang, K. G. Neoh, J. Li, “Micellization and phase transition behavior of thermosensitive poly(N-isopropylacrylamide)–poly(-caprolactone)–poly(N-isopropylacrylamide) triblock copolymers” Polymer, 49, 2008, 5084-5094.
  5. X. J. Loh, Z. X. Zhang, Y. L. Wu, T. S. Lee, J. Li, “Synthesis of novel biodegradable thermoresponsive triblock copolymers based on poly[(R)-3-hydroxybutyrate] and poly(N-isopropylacrylamide) and their formation of thermoresponsive micelles” Macromolecules, 2009, 194-202.
  6. X. J. Loh, J. Gong, M. Sakuragi, T. Kitajima, M. Liu, J. Li, Y. Ito “Surface coating with a thermoresponsive copolymer for the culture and nonenzymatic recovery of mouse embryonic stem cells” Macromolecular Bioscience, 2009, 1069-1079.
  7. X. J. Loh, W. C. D. Cheong, J. Li, Y. Ito “Novel poly(N-isopropylacrylamide)-poly[(R)-3-hydroxybutyrate]-poly(N-isopropylacrylamide) triblock copolymer surface as a culture substrate for human mesenchymal stem cells” Soft Matter, 2009, 2937-2946.
  8. X.J. Loh, P. Peh, S. Liao, C. Sng, J. Li “Controlled drug release from biodegradable thermoresponsive physical hydrogel nanofibers”, Journal of Controlled Release, 143, 2010,175-182.
  9. X. J. Loh*, S. J. Ong, Y. T. Tung, H. T. Choo “Dual responsive micelles based on poly[(R)-3-hydroxybutyrate] and poly(2-(di-methylamino)ethyl methacrylate) for effective doxorubicin delivery” Polymer Chemistry, 2013, 4, 8, 2564-2574.
  10. X. J. Loh*, S. J. Ong, Y. T. Tung, H. T. Choo “Incorporation of poly[(R)-3-hydroxybutyrate] into cationic copolymers based on poly(2-(dimethylamino)ethyl methacrylate) to improve gene delivery” Macromolecular Bioscience, 2013, In Press.

Thermogel-related

  1. X.J. Loh, S.H. Goh, J. Li “New biodegradable thermogelling copolymers having very low gelation concentrations”, Biomacromolecules, 8, 2007, 585-593
  2. X.J. Loh, S.H. Goh, J. Li “Hydrolytic degradation and protein release studies of thermogelling polyurethane copolymers consisting of poly[(R)-3-hydroxybutyrate], poly(ethylene glycol), and poly(propylene glycol)”, Biomaterials, 28, 2007, 4113-4123.
  3. X. J. Loh, J. Li “Biodegradable thermosensitive copolymer hydrogels for drug delivery” (Invited Review). Expert Opinion on Therapeutic Patents, 17(8), 2007, 965-977.
  4. X. J. Loh, Y. X. Tan, Z. Li, L. S Teo, S. H. Goh, J. Li “Biodegradable thermogelling poly(ester urethane)s consisting of poly(lactic acid) – Thermodynamics of micellization and hydrolytic degradation.” Biomaterials, 29(14), 2008, 2164–2172.
  5. X.J. Loh, S.H. Goh, J. Li “Biodegradable thermogelling poly[(R)-3-hydroxybutyrate]-based block copolymers: micellization, gelation, and cytotoxicity and cell culture studies”, Journal of Physical Chemistry B, 113, 2009, 11822-11830.
  6. X. J. Loh*, L. W. I. Cheng, J. Li “Micellization and thermogelation of poly(ether urethane)s comprising poly(ethylene glycol) and poly(propylene glycol)” Macromolecular Symposia, 2010, 296, 161-169.
  7. V. P. N. Nguyen, N. Kuo, X.J. Loh* “New biocompatible thermogelling copolymers containing ethylene-butylene segments exhibiting very low gelation concentrations”, Soft Matter, 7, 2011, 2150-2159.
  8. X. J. Loh*, V. P. N. Nguyen, N. Kuo, J. Li “Encapsulation of basic fibroblast growth factor in thermogelling copolymers preserves its bioactivity” Journal of Materials Chemistry, 21, 2011, 2246-2254.
  9. X. J. Loh*, B. J. H. Yee, F. S. Chia “Sustained delivery of paclitaxel using thermogelling poly(PEG/PPG/PCL urethane)s for enhanced toxicity against cancer cells”, Journal of Biomedical Materials: Part A, 2012, 100A, 2537–2861
  10. X. J. Loh*, W. Guerin, S. M. Guillaume “Sustained delivery of doxorubicin from thermogelling poly(PEG/PPG/PTMC urethane)s for effective eradication of cancer cells “, Journal of Materials Chemistry, 2012, 22, 21249-21256

Supramolecular polymers

  1. U. Rauwald, J. del Barrio, X. J. Loh, O.A. Scherman ““On-demand” control of thermoresponsive properties of poly(N-isopropylacrylamide) with cucurbit[8]uril host–guest complexes” Chemical Communications, 47, 2011, 6000-6002
  2. X. J. Loh, J. del Barrio, P. C. P. Toh, T. C. Lee, D. Jiao, U. A. Rauwald, E. A. Appel, O.A. Scherman “Triply Triggered Doxorubicin Release From Supramolecular Nanocontainers” Biomacromolecules, 13, 2012, 84-91.
  3. E. A. Appel, X. J. Loh, S. T. Jones, C. A. Dreiss, O. A. Scherman “Sustained release of proteins from high water content supramolecular polymer hydrogels” Biomaterials, 33, 2012, 4646-4652
  4. E. A. Appel, X. J. Loh, S. T. Jones, F. Biedermann, C. A. Dreiss, O. A. Scherman “Ultrahigh-water-content supramolecular hydrogels exhibiting multistimuli responsiveness” Journal of the American Chemical Society, 2012, 134 (28), 11767–11773.
  5. X. J. Loh, M. H. Tsai, J. del Barrio, E. A. Appel, O.A. Scherman “Triggered Insulin Release Studies of Triply Responsive Supramolecular Micelles” Polymer Chemistry, 2012, 3, 3180-3188
  6. E.A. Appel, J. del Barrio, X. J. Loh, O. A. Scherman “Supramolecular polymeric hydrogels” Chemical Society Reviews, 2012, 41, 6195-6214.
  7. D. Jiao, J. Geng, X. J. Loh, D. Das, T. C. Lee, O. A. Scherman “Supramolecular Peptide Amphiphile Vesicles through Host-Guest Complexation” Angewandte Chemie International Edition, 51, 38, 9633–9637
  8. X. J. Loh* “Supramolecular Host-Guest Polymeric Materials: Towards Biomedical Applications” Materials Horizons, 2013, In Press.

Staff Details

Email Address

mselohx@nus.edu.sg