Education
- PhD in Chemistry (1999) University of Idaho, USA
- MS in Chemistry (1996) Nanjing University, China
- BS in Chemistry (1993), Nanjing University, China
Research Area
- Cancer : Diagnostics and Therapeutics, Gene/drug delivery, Nanomedicine, Radionuclide therapy
- Cardiovascular Diseases : Imaging and Surgical, Therapy
Research Interests
- Molecular imaging probe development
- Modification of biomolecules for improved PK/PD
- Nanomedicine for gene and drug delivery (GDD)
- Ultrasensitive nanobiosensors for biomarker detection
Awards
- Society of Nuclear Medicine and Molecular Imaging (SNMMI) Fellow, 2020
- Michael J. Welch, PhD Award, SNMMI, 2019
- ACS Nano, Bioconjug Chem, and Mol Pharm Selected Highly Prolific Authors, 2017
- American Institute for Medical and Biological Engineering (AIMBE) Fellow, 2017
- Clarivate Analytics highly cited researcher, 2017/2018/2019/2020
- ACS Bioconjugate Chemistry Lectureship Award, 2016
- NIH Director’s Award, 2014
- NIBIB Mentor Award, 2012
Professional Service/Leadership
- Director, Nanomedicine Translational Research Program, NUS School of Medicine
- Research Director, Clinical Imaging Research Center, NUS School of Medicine
- Research Director, Institute of Molecular and Cell Biology, A*STAR
- Chair, Biomedical Imaging and Instrumentation I Committee, AIMBE
- President (2016-2017), Radiopharmaceutical Science Council (RPSC), Society of Nuclear Medicine and Molecular Imaging (SNMMI)
- President (2015-2017), Chinese American Society of Nanomedicine and Nanobiotechnology (CASNN)
- President (2013-2015), Chinese American Society of Nuclear Medicine and Molecular Imaging (CASNMMI)
Editorial Board
- Theranostics (founding editor, Current IF 12.4)
Editorial board member
- Acc Chem Res (IF 18.3)
- ACS Nano (IF 16.7)
- J Nucl Med (IF 9.3)
- Eur J Nucl Med Mol Imaging (IF 9.1)
- Bioeng Transl Med (IF 14.8)
- Bioconjugate Chem (IF 6.3)
Selected Publications
Cao F, Jin L, Gao Y, Ding Y, Wen H, Qian Z, Zhang C, Hong L, Yang H, Zhang J, Tong Z, Wang W, Chen X, Mao Z.
Artificial-enzymes-armed Bifidobacterium longum probiotics for alleviating intestinal inflammation and microbiota dysbiosis.
Nat Nanotechnol. 2023 Jun;18(6):617-627. doi: 10.1038/s41565-023-01346-x.
Liu C, Liu X, Xiang X, Pang X, Chen S, Zhang Y, Ren E, Zhang L, Liu X, Lv P, Wang X, Luo W, Xia N, Chen X, Liu G.
A nanovaccine for antigen self-presentation and immunosuppression reversal as a personalized cancer immunotherapy strategy. Nat Nanotechnol. 2022;17(5):531-540. doi: 10.1038/s41565-022-01098-0.
Bhatia SN, Chen X, Dobrovolskaia MA, Lammers T.
Cancer nanomedicine.
Nat Rev Cancer. 2022 Aug 8:1-7. doi: 10.1038/s41568-022-00496-9.
Li L, Zou J, Dai Y, Fan W, Niu G, Yang Z, Chen X.
Burst release of encapsulated annexin A5 in tumours boosts cytotoxic T-cell responses by blocking the phagocytosis of apoptotic cells.
Nat Biomed Eng. 2020;4(11):1102-1116. DOI: 10.1038/s41551-020-0599-5.
Chen H, Zhang W, Zhu G, Xie J, Chen X.
Rethinking cancer nanotheranostics.
Nat Rev Mater. 2017;2:17024. doi: 10.1038/natrevmats.2017.24.