Education
- PhD in Chemistry (1999) University of Idaho, USA
- MS in Chemistry (1996) Nanjing University, China
- BS in Chemistry (1993), Nanjing University, China
Research Area
- Cancer : Diagnostics and Therapeutics, Others, Others: Gene/drug delivery, Others: Nanomedicine, Others: Radionuclide therapy
- Cardiovascular Diseases : Imaging and Surgical, Therapy
Research Interest
- Molecular imaging probe development
- Modification of biomolecules for improved PK/PD
- Nanomedicine for gene and drug delivery (GDD)
- Ultrasensitive nanobiosensors for biomarker detection
Recent Publications
- Feng Z, Zhang X, Zhou J, Li Q, Chu L, Di G, Xu Z, Chen Q, Wang M, Jiang X, Xia H, Chen X. An in vitro-transcribed circular RNA targets the mitochondrial inner membrane cardiolipin to ablate EIF4G2+/PTBP1+ pan-adenocarcinoma. Nat Cancer. 2023 Oct 16. doi: 10.1038/s43018-023-00650-8.
- Fu H, Huang J, Zhao T, Wang H, Chen Y, Xu W, Pang Y, Guo W, Sun L, Wu H, Xu P, Su B, Zhang J, Chen X, Chen H. Fibroblast Activation Protein-Targeted Radioligand Therapy with 177Lu-EB-FAPI for Metastatic Radioiodine Refractory Thyroid Cancer: First-in-Human, Dose-Escalation Study. Clin Cancer Res. 2023 Oct 6. doi: 10.1158/1078-0432.CCR-23-1983.
- Cao F, Jin L, Zhang C, Gao Y, Qian Z, Wen H, Yang S, Ye Z, Hong L, Yang H, Tong Z, Cheng L, Ding Y, Wang W, Yu G, Mao Z, Chen X. Engineering Clinically Relevant Probiotics with Switchable “nano-promoter” and “nano-effector” for Precision Tumor Therapy. Adv Mater. 2023 Oct 3:e2304257. doi: 10.1002/adma.202304257.
- Zhang J, Zhao T, Jakobsson V, Chen X Clinical translation of radiotheranostics for precision oncology. Nat Rev Bioeng. 2023; 1: 612–614. doi: 10.1038/s44222-023-00106-9
- Shi C, Zhang Q, Yao Y, Zeng F, Du C, Nijiati S, Wen X, Zhang X, Yang H, Chen H, Guo Z, Zhang X, Gao J, Guo W, Chen X, Zhou Z. Targeting the activity of T cells by membrane surface redox regulation for cancer theranostics. Nat Nanotechnol. 2023 Jan;18(1):86-97. doi: 10.1038/s41565-022-01261-7.
Selected Publications
- Cao F, Jin L, Gao Y, Ding Y, Wen H, Qian Z, Zhang C, Hong L, Yang H, Zhang J, Tong Z, Wang W, Chen X, Mao Z. Artificial-enzymes-armed Bifidobacterium longum probiotics for alleviating intestinal inflammation and microbiota dysbiosis. Nat Nanotechnol. 2023 Jun;18(6):617-627. doi: 10.1038/s41565-023-01346-x.
- Liu C, Liu X, Xiang X, Pang X, Chen S, Zhang Y, Ren E, Zhang L, Liu X, Lv P, Wang X, Luo W, Xia N, Chen X, Liu G. A nanovaccine for antigen self-presentation and immunosuppression reversal as a personalized cancer immunotherapy strategy. Nat Nanotechnol. 2022 May;17(5):531-540. doi: 10.1038/s41565-022-01098-0.
- Bhatia SN, Chen X, Dobrovolskaia MA, Lammers T. Cancer nanomedicine. Nat Re-v Cancer. 2022 Oct;22(10):550-556. doi: 10.1038/s41568-022-00496-9.
- Li L, Zou J, Dai Y, Fan W, Niu G, Yang Z, Chen X. Burst release of encapsulated annexin A5 in tumours boosts cytotoxic T-cell responses by blocking the phagocytosis of apoptotic cells. Nat Biomed Eng. 2020 Nov;4(11):1102-1116. doi: 10.1038/s41551-020-0599-5.
- Chen H, Zhang W, Zhu G, Xie J, Chen X. Rethinking cancer nanotheranostics. Nat Rev Mater. 2017;2:17024. doi: 10.1038/natrevmats.2017.24.
Professional Service/Leadership
- Director, Nanomedicine Translational Research Program, NUS School of Medicine
- Research Director, Clinical Imaging Research Center, NUS School of Medicine
- Research Director, Institute of Molecular and Cell Biology, A*STAR
- Chair, Biomedical Imaging and Instrumentation I Committee, AIMBE
- President (2016-2017), Radiopharmaceutical Science Council (RPSC), Society of Nuclear Medicine and Molecular Imaging (SNMMI)
- President (2015-2017), Chinese American Society of Nanomedicine and Nanobiotechnology (CASNN)
- President (2013-2015), Chinese American Society of Nuclear Medicine and Molecular Imaging (CASNMMI)
Editorial Board
- Theranostics (founding editor, Current IF 12.4)
Editorial board member
- Acc Chem Res (IF 18.3)
- ACS Nano (IF 16.7)
- J Nucl Med (IF 9.3)
- Eur J Nucl Med Mol Imaging (IF 9.1)
- Bioeng Transl Med (IF 14.8)
- Bioconjugate Chem (IF 6.3)
Prof. Xiaoyuan (Shawn) Chen received his PhD in Chemistry from the University of Idaho (1999). After two postdocs at Syracuse University and Washington University in St. Louis, he started his Assistant Professorship in 2002 and joined Stanford in 2004. He was promoted to Associate Professor in 2008. He then moved to NIH in 2009 and became a Senior Investigator and Chief of the Laboratory of Molecular Imaging and Nanomedicine (LOMIN) at the National Institute of Biomedical Imaging and Bioengineering (NIBIB), NIH. He is currently Nasrat Muzayyin Professor in Medicine and Technology, Yong Loo Lin School of Medicine and College of Design and Engineering, National University of Singapore. Dr. Chen has published over 1000 peer-reviewed papers (H-index >190, total citations > 130,000 based on google scholar) and numerous books and book chapters. He is the founding editor of journal “Theranostics” (IF = 12.4 based 2023 Journal Citation Report). He was elected as AIMBE Fellow (2017) and SNMMI Fellow (2020), joined Advanced Materials Hall of Fame (2023), received JBN Trailblazer Award (2023), SNMMI Michael J. Welch Award (2019), ACS Bioconjugate Chemistry Lecturer Award (2016), NIH Director’s Award (2014), NIBIB Mentor Award (2012). He is also the Past President of Chinese-American Society of Nuclear Medicine and Molecular Imaging (CASNMMI), Past President of the Radiopharmaceutical
Science Council (RPSC), Society of Nuclear Medicine and Molecular Imaging (SNMMI), and Past President of the Chinese American Society of Nanomedicine and Nanobiotechnology (CASNN).
Lab website: https://www.tntchenlab.com/