Dr. CHEOW Lih Feng

Education

• PhD, Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 2012
• BSc, Electrical and Computer Engineering, Cornell University, 2006

Research Interest

1. Single cell analysis
2. Platforms for spatio-temporal analysis of single cell
3. Next generation sequencing technologies
4. Microfluidics systems for diagnosis and therapeutics
5. Microfluidics technology development

Selected Awards & Honours

1. Helen Carr Peak Research Prize, MIT, 2011
2. National Science Scholarship (PhD), A*STAR, 2007
3. National Science Scholarship (BS), A*STAR, 2002

Selected Journal Publications

Single Cell Analysis

1. Cheow, L.F., Courtoise, E.T., Tan, Y., Viswanathan, R., Xing, Q., Tan, D.S.W., Robson, P., Loh, Y.-H., Quake, S.R., Burkholder, W.F. (2016) Single cell multimodal profiling reveals cellular epigenetic heterogeneity. Nature Methods. 13: 933-836
2. Cheow, L.F., Quake, S.R., Burkholder, W.F., and Messerschimdt, D.M. (2015). Multiplexed locus-specific analysis of DNA methylation in single cells. Nature Protocols. 10(4): 619-631
3. Cheow, L.F., Sarkar, A, Kolitz, S., Lauffenburger, D., and Han, J. (2014). Detecting kinase activities from single cell lysate using concentration-enhanced mobility shift assay. Anal. Chem. 86(15): 7455-7462
4. Lorthongpanich, C.*, Cheow, L.F.*, Balu, S., Quake, S.R., Knowles, B.B., Burkholder, W.F., Solter, D, and Messerschmidt, D.M. (2013). Single-cell DNA methylation analysis reveals epigenetic chimerism in preimplantation embryos. Science. 341(6150): 1110-1112

Microfluidics

5. Cheow, L.F., Viswanathan, R., Chin, C.S., Jennifer, N., Jones, R.C., Guccione, E., Quake, S.R., and Burkholder, W.F. (2014). Multiplexed analysis of protein-ligand interactions by fluorescence anisotropy in a microfluidic platform. Anal. Chem. 86(19): 9901-9908
6. Cheow, L.F., Bow, H., and Han, J. (2012). Continuous-flow biomolecule concentration and detection in a slanted nanofilter array. Lab Chip. 12: 4441-4448
7. Cheow, L.F., and Han, J. (2011). Continuous signal enhancement for sensitive aptamer affinity probe electrophoresis assay using electrokinetic concentration. Anal. Chem. 83(18): 7086-7093
8. Ko, S.H., Kim, S.J., Cheow, L.F., Li, L.D., Kang, K.H., and Han, J. (2011). Massively parallel concentration device for multiplexed immunoassays. Lab Chip. 11: 1351-1358
9. Cheow, L.F., Ko, S.H., Kim, S.J., Kang, K.H., and Han, J. (2010). Increasing the sensitivity of enzyme-linked immunosorbent assay using multiplexed electrokinetic concentrator. Anal. Chem. 82(8): 7086-7093
10. Yobas, L., Cheow, L.F., Tang, K.C., Yong, S.E., Ong, K.J., Wong, L., Teo, C.Y., Ji, H., Rafaeh, S., and Yu,C. (2009). A self-contained fully-enclosed microfluidic cartridge for lab on a chip. Biomed. Microdev. 11(6): 1279-1288
11. Luo, L.W., Teo, C.Y., Ong, W.L., Tang, K.C., Cheow, L.F., and Yobas, L. (2007). Rapid prototyping of microfluidic systems using a laser-patterned tape. J. Micromech. Microeng. 17:107-111
12. Schoch, R.B., Cheow, L.F., and Han, J. (2007). Electrical detection of fast reaction kinetics in nanochannels with an induced flow. Nano Letters. 7(12): 3895-3900
13. Cheow, L.F., Yobas, L., and Kwong, D.L. (2007). Digital microfluidics: Droplet based logic. Appl. Phys. Lett. 90: 054107