Education
· PhD in Physiology & Pharmacology, RMIT University, Melbourne, Australia, 2012
· B.Sc. (First Class Honours, Pharmacology), University of Melbourne, Melbourne, Australia, 2007
· B.Sc. (Majors: Pharmacology & Microbiology), University of Western Australia, Perth, Australia, 2006
Research & Educational Interest
· Pharmacology & Therapeutics
· Biomedical Physiology & Engineering
· Serious games in Education
· Game-based learning & AI-based assessment
Selected Awards & Honours
· Singapore Teaching & Academic Research Talent Scheme, MOE Singapore, 2017
Selected Publications
Journal Publications (Disciplinary Research)
1. M. SHANMUGHAM, A.G. DEVASIA, Y.L. CHIN, K.H. CHEONG, E.S. ONG, S. BELLAGER, A. RAMASAMY, C.H. LEO (2023). Time-dependent specific molecular signatures of inflammation and remodelling are associated with trimethylamine-N-oxide (TMAO)-induced endothelial cell dysfunction. Sci Report; 13, 20303.
2. S.S.Y. TAN, M. SHANMUGHAM, Y.L. CHIN, J. AN, C.K. CHUA, E.S. ONG, C.H. LEO (2023). Pressurized Hot Water Extraction of Mangosteen Pericarp and Its Associated Molecular Signatures in Endothelial Cells. Antioxidants, 12 (11), 1932.
3. C.H. LEO & E.S. ONG (2023). Recent advances in the combination of organic solvent free extraction, chemical standardization, antioxidant assay and cell culture metabolomics for functional food and its by-product. Crit Rev Food Sci Nutr, 1-15. DOI: 10.1080/10408398.2023.2245040.
4. J.D. TAN, C.P. LEE, S.Y. FOO, J.C.W. TAN, S.S.Y. TAN, E.S. ONG, C.H. LEO*, & M. HASHIMOTO (2023). 3D printability and biochemical analysis of revalorised orange peel waste. Int J Bioprint, 9, 776. *Joint corresponding author
5. C.H. LEO, J.L.M. OU, E.S. ONG, C.X. QIN, L.J. PARRY, R.H. RITCHIE & H.H. NG (2023). Relaxin elicits renoprotective actions accompanied by increasing bile acid levels in streptozotocin-induced diabetic mice. Biomedicine & Pharmacotherapy 162, 114578.
6. M. SHANMUGHAM, S. BELLAGER & C.H. LEO (2023). Gut-Derived Metabolite, Trimethylamine-N-oxide (TMAO) in Cardio-Metabolic Diseases: Detection, Mechanism, and Potential Therapeutics. Pharmaceuticals, 16 (4), 504.
7. M. JELINIC, K.L JACKSON, K. O’SULLIVAN, J. SINGH, T. GIDDY, M. DEO, L.J. PARRY, R.H. RITCHIE, O.L. WOODMAN, G.A. HEAD, C.H. LEO* & C.X. QIN (2023). Endothelium-dependent relaxation is impaired in Schlager hypertensive (BPH/2J) mice by region-specific mechanisms in conductance and resistance arteries. Life Sci, 121542. *Joint Senior & corresponding author
8. Z.Y. HU, B. ZHANG, L.J.Y. LIM, W.Z.K. LOH, D. YU, B.W.Q. TAN, M.C. LIANG, Z.W. HUANG, C.H. LEO, H. HUANG, T.W. SOONG (2022). S-Nitrosylation-mediated reduction of CaV1.2 surface expression and open probability underlies attenuated vasoconstriction induced by nitric oxide. Hypertension. 79, 2854-2866.
9. C.H. LEO*, S.Y. FOO, J.C.W. TAN, U.X. TAN, C.K. CHUA & E.S. ONG (2022). Green extraction of orange peel waste reduces TNFα-induced vascular inflammation and endothelial dysfunction. Antioxidants, 11(9), 1768. *Corresponding author
10. E.S. ONG, J. LOW, J.C.W. TAN, S.Y. FOO & C.H. LEO (2022). Valorization of Avocado Seeds with Antioxidant Capacity using Pressurized Hot Water Extraction. Sci Report; 12, 1-11.
11. Y. ZHANG, A.Y. LEE, KANITTHAMNIYOM. P, C.P LEE, A. ZHOU, J. AN, M. HASHIMOTO, U.X. TAN, C.H. LEO, G. WONG, C.K. CHUA, A. PANT (2022). Systematic Engineering Approach for Optimisation of Multi-Component Alternative Protein-Fortified 3D Printing Food Ink. Food Hydrocolloids, 131, 107803.
Journal Publications (Educational Research)
1. C.E. CHU, G.S.W. CHEONG, A. MISHRA, Y. WEN, C.H. LEO, D.J. YEO, K.H. CHEONG (2024). Enhancing Biology Laboratory Learning: Student Perceptions of Performing Heart Dissection with Virtual Reality. IEEE Access, 10.1109/ACCESS.2024.3394713
2. R.B.S. MOHAMED SALIM, J.S CHEN, C.H. LEO & B. RAI (2023). Design and development of MemoryTrail virtual reality game to study brain and memory processes in a fun and interactive manner. Journal of Applied Learning & Teaching, 6:1, DOI: https://doi.org/10.37074/jalt.2023.6.S1.3
3. B. RAI, H.S. TAN & C.H. LEO (2019). Bringing play back into the biology classroom with the use of gamified virtual lab simulations. Journal of Applied Learning & Teaching, 2:2, doi: 10.37074/jalt.2019.2.2.7
Books / Book Chapters
1. C.K. CHUA, W.Y. YEONG, H.W. TAN, Y. ZHANG, U.X. TAN, C.H. LEO, M. HASHIMOTO, G. WONG, J.J.Y. TAN, A. PANT (2022). Digital Gastronomy: From 3D food printing to personalized nutrition. World Scientific Publishing