Education
- PhD. Nanyang Technological University, 2005
- BE. Huazhong University of Science & Technology, 1999
- BEco, Huazhong University of Science & Technology, 1999
Professional Experience:
- Principal Investigator, National Heart Research Institute Singapore, National Heart Centre Singapore
- Associate Professor, Cardiovascular Science ACP, Duke-NUS
- Associate Professor, Signature Programme of Cardiovascular Metabolic and Disorder, Duke-NUS
- Guest Professor, Huazhong University Science and Technology, Wuhan, China
- Visiting Senior Consultant, Wuhan Asia Heart Hospital, (2014 – 2016)
- International Technical Committee Member, Society of Engineering in Medicine and Biology, Cardiovascular and Respiratory Theme
- Committee Member, Society of Engineering in Medicine and Biology, Singapore Chapter
- Committee Member, International Society of Magnetic Resonance in Medicine, Singapore Chapter
Research Interest:
- Biomedical imaging and artificial intelligence to better strategy the patients for proper treatment
- Coronary computational modelling to investigate the coronary flow, pressure and fractional flow reserve (FFR) in coronary artery disease
- Heart computational modelling to investigate the mechanism of cardiac dysfunction and dyssynchrony
- Pre-clinical and clinical cardiac MRI to investigate right ventricular and pulmonary circulation in TOF and PAH
- Clinical CT to assess calcium score, epicardial adipose tissue, stenosis and plaque by AI
- Cardiovascular ageing – underlying atrial and vascular stiffness and metabolomics
Selected Awards and Honours:
- GCEO outstanding research award, SingHealth Excellent Award 2021 (2021)
- “Huanghe Bei” Innovation and Entrepreneurship Competition, Third Prize, China (2015)
- Singhealth Publish Award (Medical Research), SingHealth, Singapore (2014)
- Best Publication Award, Gold, Academy of Medicine, Singapore (2013)
- Sejong Medical Award from Asia-Pacific Paediatric Cardiac Society (2012)
- Young Investigator Award, First Prize, ASEAN Federation of College in Cardiology (2012)
- Young Investigator Award, First Prize, Singapore Cardiac Society (2012)
- Young Investigator Award, First Prize, Singapore Cardiac Society (2011)
- Best Abstract Award, Singapore Cardiac Society (2011)
- Save the Children Korea Travel Grant, APPCS & APSACHD, Japan (2010)
Selected Journal Publications
1, Zhao X, Hu LW, Leng S, Tan RS, Chai P, Bryant J, Teo L, Fortier M, Yeo TJ, Ouyang RZ, Allen J, Hughes M, Garg P, Zhang S, van der Geest R, Yip J, Tan TH, Tan JL, Zhong YM, Zhong L. Ventricular flow analysis and its association with exertional capability in repaired tetralogy of Fallot: 4D flow cardiovascular magnetic resonance study. Journal of Cardiovascular Magnetic Resonance; 2022:24:4.
2, Juffermans JF, Minderhoud SCS, Wittgren J, Kilburg A, Ese A, Fidock B, Zheng YC, Zhang JM, Blanken C, Lamb H, Goeman JJ, Carlsson M, Zhao S, Panken RN, Ooij PV, Zhong L, Chen X, Garg P, Emrich T, Hirsch A, Toger J, Westenberg JJM. Multicenter consistency assessment of valvular flow quantification with automated valve tracking in 4D Flow MRI. JACC Cardiovascular Imaging 2021; Jul;14(7):1354-1366.
3, Chioh FWJ, Young BE, Fong SW, Wu KX, Siau A, Krishnan S, Teo LLY, Gao F, Tan RS, Zhong L, Koh AS, Renia L, Ng LFP, Lye DC, Cheung C. Convalescent COVID-19 patients are susceptible to endothelial dysfunction due to persistent immune activation. eLife 2021;10:e64909.
4, Leng S, Tan RS, Guo JJ, Chai P, Zhang GC, Teo L, Ruan W, Yeo TJ, Zhao XD, Allen JC, Tan JL, Yip JW, Chen Y, Zhong L. Cardiovascular magnetic resonance assessed fast global longitudinal strain parameters add diagnostic and prognostic insights in right ventricular volume and pressure overloading. Journal of Cardiovascular Magnetic Resonance 2021; 23(1):38.
5, Kovalik JP, Zhao XD, Gao F, Leng S, Chow V, Chew H, Teo LY, Tan RS, Ewe SH, Tan HC, Ning WH, Ching JH, Keng BMH, Koh WP, Zhong L, Koh AS. Amino acid differences between diabetic older adults and non-diabetic older adults and their association with cardiovascular function. Journal of Molecular and Cellular Cardiology 2021; 58:63-71.
- Garg P, Swift A, Zhong L, Carlhall CJ, Ebbers T, Westenberg J, Hope M, Bucciarelli-Ducci C, Bax JJ, Myerson S. Mitral valve regurgitation assessment by cardiovascular magnetic resonance imaging. Nature Reviews Cardiology 2020;17(5):298-312.7. Leng S, Ge H, He J, Kong L, Tan RS, Zhao XD, Allen JC, Hansenloy DJ, Zhong L, Pu J. Long-term prognostic value of cardiac MRI left atrial strain in ST-segment elevation myocardial infarction. Radiology 2020; 296(2):299-309.8. Zhong L, Schrauben EM, Garcia J, Uribe S, Grieve SM, Eibaz MM, Barker AJ, Geiger J, Nordmeyer S, Marsden A, Carlsson M, Tan RS, Garg P, Westenberg JJM, Markl M, Ebbers T. Intracardiac 4D flow MRI in congenital heart disease: recommendations on behalf of the ISMRM Flow & Motion Study Group. J Magn Reson Imaging 2019; 50:677-681 (Cover article).9. Leng S, Dong Y, Wu Y, Zhao XD, Ruan W, Zhang GC, Allen JC, Koh AS, Tan RS, Yip J, Tan JL, Chen Y, Zhong L. Impaired CMR-derived rapid semi-automated right atrial longitudinal strain is associated with decompensated hemodynamics in pulmonary arterial hypertension. Circulation: Cardiovascular Imaging 2019; 12;e008582.10. Leng S, Tan RS, Zhao XD, Koh A, Zhong L. Validation of rapid semi-automated method to assess left atrial longitudinal phasic strains on cine cardiovascular magnetic resonance imaging. Journal of Cardiovascular Magnetic Resonance 2018; 20(1):71