Dr Li Jun

Dr. LI Jun

Professor

Research Interest

  1. Design of Novel Biodegradable Polymers and Hydrogels
  2. Self-assembly and Nano-Structures of Novel Macromolecular Systems
  3. Applications of Novel Biomaterials for Drug/Gene Delivery and Tissue Engineering

Research Lab Website : Supramolecular Lab 

Modules Taught

  • BN3301 Introduction to Biomaterials
  • BN5201 Advanced Biomaterials

Selected Journal Publications

  1. Wen Y, Bai H, Zhu J, Song X, Tang G*, Li J*, A supramolecular platform for controlling and optimizing molecular architectures of siRNA targeted delivery vehicles, Science Advances, 2020, 6, eabc2148. DOI: 10.1126/sciadv.abc2148
  2. Zhu J, Tan WK, Song X, Gao Z, Wen Y, Ong CN, Loh CS, Swarup S, Li J*, Converting okara to superabsorbent hydrogels as soil supplements for enhancing the growth of choy sum (brassica sp.) under water-limited conditions, ACS Sustainable Chemistry & Engineering, 2020, 8(25), 9425-9433. Issue 25 Front Cover Article. DOI: 10.1021/acssuschemeng.0c02181
  3. Zhu J, Song X, Tan WK, Wen Y, Gao Z, Ong CN, Loh CS, Swarup S, Li J*, Chemical modification of biomass okara using poly(acrylic acid) through free radical graft polymerization, Journal of Agricultural and Food Chemistry, 2020. DOI: 10.1021/acs.jafc.0c01818
  4. Song X, Zhang Z, Zhu J, Wen Y, Zhao F, Lei L, Phan-Thien N, Khoo BC, Li J*, Thermoresponsive hydrogel induced by dual supramolecular assemblies and its controlled release property for enhanced anticancer drug delivery, Biomacromolecules, 2020, 21 (4), 1516-1527. Issue 4 Front Cover Article. DOI: 10.1021/acs.biomac.0c00077
  5. Ooi YJ, Wen Y, Zhu JL, Song X, Li J*, Surface charge switchable polymer/DNA nanoparticles responsive to tumor extracellular pH for tumor-triggered enhanced gene delivery, Biomacromolecules, 2020, 21 (3), 1136−1148. DOI: 10.1021/acs.biomac.9b01521
  6. Liu L, Lam WMR, Yang Z, Wang M, Ren X, Hu T, Li J, Goh JCH, Wang HK*, Improving the handling properties and long-term stability of polyelectrolyte complex by freeze-drying technique for low-dose bone morphogenetic protein 2 delivery, Journal of Biomedical Materials Research Part B, 2020, 108B, 2450−2460. DOI: 10.1002/jbm.b.34577
  7. Liu M, Wen YT, Song X, Zhu JL, Li J*, A smart thermoresponsive adsorption system for efficient copper ion removal based on alginate-g-poly(N-isopropylacrylamide) graft copolymer, Carbohydrate Polymers, 2019, 219, 280-289. DOI: 10.1016/j.carbpol.2019.05.018
  8. Higashi T, Morita K, Song X, Zhu JL, Tamura A, Yui N, Motoyama K, Arima H*, Li J*, One-pot synthesis of cyclodextrin-based radial poly [n] catenanes, Communications Chemistry, 2019, 2, 78. DOI: 10.1038/s42004-019-0180-x
  9. Zhu JL, Yu SWK, Chow PKH, Tong YW, Li J*, Controlling injectability and in vivo stability of thermogelling copolymers for delivery of yttrium-90 through intra-tumoral injection for potential brachytherapy, Biomaterials, 2018, 180, 163-172.
  10. Assah E, Goh W, Zheng XT, Lim TX, Li J, Lane D, Ghadessy F, Tan YN*, Rapid colorimetric detection of p53 protein function using DNA-goldnanoconjugates with applications for drug discovery and cancerdiagnostics,Colloids and Surfaces B: Biointerfaces, 2018, 169, 214–221.
  11. Wen Y and Li J*, Ultrastable micelles boost chemotherapy, Nature Biomedical Engineering, 2018, 2(5), 273–274.
  12. Liu M, Song X, Wen Y, Zhu J, Li J*, Injectable Thermoresponsive Hydrogel Formed by Alginate-g-Poly(N-isopropylacrylamide) That Releases Doxorubicin-Encapsulated Micelles as a Smart Drug Delivery System, ACS Appl. Mater. Interfaces, 2017, 9(41), 35673–35682.
  13. Shi P, Abbah SA, Chuah YJ, Li J, Zhang Y, He P, Wong HK, Goh JCH*, Yolk shell nanocomposite particles as bioactive bone fillers and growth factor carriers, Nanoscale, 2017, 9, 14520–14532.
  14. Song X, Zhu J, Wen Y, Zhao F, Zhang Z, Li J*, Thermoresponsive supramolecular micellar drug delivery system based on star-linear pseudo-block polymer consisting of β-cyclodextrin-poly(N-isopropylacrylamide) and adamantyl-poly(ethylene glycol), Journal of Colloid and Interface Science, 2017, 490, 372-379.
  15. Song X, Wen Y, Zhu J, Zhao F, Zhang Z, Li J*, Thermoresponsive Delivery of Paclitaxel by β-Cyclodextrin-based Poly(N-isopropylacrylamide) Star Polymer via Inclusion Complexation, Biomacromolecules, 2016, 17, 3957-3963.
  16. Wang M, Lam RWM, Abbah SA, Hu T, Toh SY, Cool S, Bhakoo K, Li J, Goh JCH, Wong HK*, Heparin-Based Polyelectrolyte Complex Enhances the Therapeutic Efficacy of Bone Morphogenetic Protein-2 for Posterolateral Fusion in a Large Animal Model, Spine, 2016, 41(15), 1199-1207.
  17. Higashi T, Li J,* Song X, Zhu J, Taniyoshi M, Hirayama F, Iohara D, Motoyama K, Arima H,* Thermoresponsive Formation of Dimethyl Cyclodextrin Polypseudorotaxanes and Subsequent One-Pot Synthesis of Polyrotaxanes, ACS Macro Letters, 2016, 5, 158-162.
  18. Zhu JL, Liu KL, Wen Y, Song X, Li J*, Host–guest interaction induced supramolecular amphiphilic star architecture and uniform nanovesicle formation for anticancer drug delivery, Nanoscale, 2016, 8, 1332-1337.
  19. Hu T, Abbah SA, Toh SY, Wang M, Lam RWM, Naidu M, Bhakta G, Cool SM, Bhakoo K, Li J, Goh JCH, Wong HK*, Bone marrow-derived mesenchymal stem cells assembled with low-dose BMP-2 in a three-dimensional hybrid construct enhances posterolateral spinal fusion in syngeneic rats, The Spine Journal, 2015, 15, 2552-2563
  20. Wang M, Abbah SA, Hu T, Lam RWM, Toh SY, Liu T, Cool SM, Bhakoo K, Li J, Goh JCH, Wong HK*, Polyelectrolyte Complex Carrier Enhances Therapeutic Efficiency and Safety Profile of Bone Morphogenetic Protein-2 in Porcine Lumbar Interbody Fusion Model, Spine, 2015, 40, 964-973.
  21. Hu T, Abbah SA, Wang M, Toh SY, Lam RWM, Naidu M, Bhakta G, Cool SM, Bhakoo K, Li J, Goh JCH, Wong HK*, Novel Protamine-Based Polyelectrolyte Carrier Enhances Low-Dose rhBMP-2 in Posterolateral Spinal Fusion, Spine, 2015, 40, 613-621.
  22. Yin H, Zhao F, Zhang D, Li J*, Hyaluronic acid conjugated β-cyclodextrin-oligoethylenimine star polymer for CD44-targeted gene delivery,International Journal of Pharmaceutics, 2015, 483, 169-179.
  23. Zhang QY, Wang ZY, Wen F, Ren L, Li J, Teoh SH, Thian ES*, Gelatin–siloxane nanoparticles to deliver nitric oxide for vascular cell regulation: Synthesis, cytocompatibility, and cellular responses, Journal of Biomedical Materials Research Part A, 2015, 103, 929-938.
  24. Liu X, Yin H, Zhang Z, Diao B, Li J*, Functionalization of lignin through ATRP grafting of poly(2-dimethylaminoethyl methacrylate) for gene delivery, Colloids and Surfaces B Biointerfaces, 2015, 125, 230-237.
  25. Diao B, Zhang Z, Zhu J, Li J*, Biomass-based thermogelling copolymers consisting of lignin and grafted poly(Nisopropylacrylamide), poly(ethylene glycol), and poly(propylene glycol), RSC Advances, 2014, 4, 42996-43003.
  26. Wen Y, Zhang Z, Li J*, Highly Efficient Multifunctional Supramolecular Gene Carrier System Self-Assembled from Redox-Sensitive and Zwitterionic Polymer Blocks, Advanced Functional Materials, 2014, 24, 3874-3884.
  27. Zhang Z, Ni X, Li J*, Cationic Brush-like Terpolymer with pH Responsive Thickening Behavior in a Surfactant System, Polymer International, 2014, 63, 1584-1592.
  28. Li J*, In-focus Hydrogels and Water-Soluble Polymers, Polymer International, 2014, 63, 1537-1538. Zhao F, Yin H, Li J*, Supramolecular self-assembly forming a multifunctional synergistic system for targeted co-delivery of gene and drug, Biomaterials, 2014, 35, 1050-1062.
  29. Shi P, Abbah SA, Saran K, Zhang Y, Li J, Wong HK, Goh JCH*, Silk Fibroin-Based Complex Particles with Bioactive Encrustation for Bone Morphogenetic Protein 2 Delivery, Biomacromolecules, 2013, 14, 4465-4474.
  30. Li ZB, Li J*, Control of Hyperbranched Structure of Polycaprolactone/Poly(ethylene glycol) Polyurethane Block Copolymers by Glycerol and Their Hydrogels for Potential Cell Delivery, The Journal of Physical Chemistry B, 2013, 117, 14763-14774.
  31. Liu C, Zhang Z, Liu X, Ni X, Li J*, Gelatin-based hydrogels with β-cyclodextrin as a dual functional component for enhanced drug loading and controlled release, RSC Advances, 2013, 3, 25041-25049.
  32. Wang G, Yin H, Ng JCY, Cai L, Li J*, Tang BZ, Liu B*, Polyethyleneimine-grafted hyperbranched conjugated polyelectrolytes: synthesis and imaging of gene delivery, Polymer Chemistry, 2013, 4, 5297-5304.
  33. Zhang Z, Liu KL, Li J*, A Thermo-Responsive Hydrogel Formed from a Star-Star Supramolecular Architecture, Angewandte Chemie International Edition, 2013, 52, 6180-6184.
  34. Ping Y, Hu Q, Tang G, Li J*, FGFR-targeted gene delivery mediated by supramolecular assembly between β-cyclodextrin-crosslinked PEI and redox-sensitive PEG, Biomaterials, 2013, 34, 6482-6494
  35. Zhao F, Yin H, Zhang ZX, Li J*, Folic Acid Modified Cationic g-Cyclodextrin-oligoethylenimine Star Polymer with Bioreducible Disulfide Linker for Efficient Targeted Gene Delivery, Biomacromolecules, 2013, 14, 476-484.
  36. Liu CD, Zhang Z, Liu KL, Ni X, Li J*, Biodegradable thermogelling poly(ester urethane)s consisting of poly(1,4-butylene adipate), poly(ethylene glycol), and poly(propylene glycol), Soft Matter, 2013, 9 (3), 787-794.
  37. Wu YL, Yin H, Zhao F, Li J*, Multifunctional Hybrid Nanocarrier Consisting of Supramolecular Polymer and Quantum Dot for Simultaneous Dual Therapeutics Delivery and Cellular Imaging, Advanced Healthcare Materials, 2013, 2, 297-301.
  38. Li Z, Zhang Z, Liu KL, Ni X, Li J*, Biodegradable Hyperbranched Amphiphilic Polyurethane Multiblock Copolymers Consisting of Poly(propylene glycol), Poly(ethylene glycol), and Polycaprolactone as in situ Thermogels, Biomacromolecules, 2012, 13, 3977-3989.
  39. Li Z, Yin H, Zhang Z, Liu KL, Li J*, Supramolecular Anchoring of DNA Polyplexes in Cyclodextrin-Based Polypseudorotaxane Hydrogels for Sustained Gene Delivery, Biomacromolecules, 2012, 13, 3162-3172.
  40. She Z, Wang C, Li J*, Sukhorukov GB, and Antipina MN*, Encapsulation of Basic Fibroblast Growth Factor by Polyelectrolyte Multilayer Microcapsules and Its Controlled Release for Enhancing Cell Proliferation, Biomacromolecules, 2012, 13, 2174-2180.
  41. Bao HQ, Ping Y, Pan YZ, Li L*, Li J, Gan LH, Thermo-responsive transfection of DNA complexes with well-defined chitosan terpolymers, Soft Matter, 2012, 8, 2518-2526.
  42. Li J*, Supramolecular Polymers for Potential Biomedical Applications, Advanced Materials Research, 2012, 410, 94-97
  43. Chen B, Liu KL, Zhang ZX, Ni X, Goh SH, Li J*, Supramolecular hydrogels formed by pyrene-terminated poly(ethylene glycol) star polymers through inclusion complexation of pyrene dimers with g-cyclodextrin, Chemical Communications, 2012, 48, 5638-5640.
  44. Zhu JL, Liu KL*, Zhang ZX, Zhang XZ, Li J*, Amphiphilic star-block copolymers and supramolecular transformation of nanogel-like micelles to nanovesicles, Chemical Communications, 2011, 47, 12849-12851.
  45. Liu KL, Zhang ZX, Li J*, Supramolecular Hydrogels Based on Cyclodextrin-Polymer Polypseudorotaxanes: Materials Design and Hydrogel Properties, Soft Matter, 2011, 7, 11290-11297.
  46. Li M, Xu L, Wang L, Wu YP, Li J, Neoh KG, Kang ET*, Clickable poly(ester amine) dendrimer-grafted Fe3O4 nanoparticles prepared via successive Michael addition and alkyne – azide click chemistry, Polymer Chemistry, 2011, 2(6), Part 1312.
  47. Ping Y, Liu CD, Zhang ZX, Liu KL, Chen JH, Li J*, Chitosan-graft-(PEI-b-cyclodextrin) copolymers and their supramolecular PEGylation for DNA and siRNA delivery, Biomaterials, 2011, 32, 8328-8341.
  48. Bao HQ, Pan YZ, Ping Y, Sahoo NG, Wu TF, Li L*, Li J, Gan LH, Chitosan-Functionalized Graphene Oxide as a Nanocarrier for Drug and Gene Delivery, Small, 2011, 7(11), 1569 – 1578.
  49. Liu MZ, Xu MY, Loh XJ, Abe H, Tsumuraya T, Fujii I, Li J, Son TI, Ito, Y*, PEGylated antibody in organic media, Journal of Bioscience and Bioengineering, 2011, 111(5), 564 – 568.
  50. Hu QD, Fan H, Ping Y, Liang WQ, Tang GP*, Li J*, Cationic supramolecular nanoparticles for co-delivery of gene and anticancer drug, Chemical Communications, 2011, 47, 5572 – 5574.
  51. 19. Li JJ, Zhao F, Li J*, Supramolecular Polymers base on Cyclodextrins for Drug and Gene Delivery, Advances in Biochemical Engineering-Biotechnology, 2011, 125, 207-250.
  52. Li JJ, Zhao F, Li J*, Polyrotaxanes for applications in life science and biotechnology, Applied Microbiology and Biotechnology, 2011, 90(2), 427 – 443.
  53. Loh XJ*, Vu PNN, Kuo NY, Li J, Encapsulation of basic fibroblast growth factor in thermogelling copolymers preserves its bioactivity, Journal of Materials Chemistry, 2011, 2011, 21(7), 2246 – 2254.
  54. Zhang ZX, Liu KL, Li J*, Self-Assembly and Micellization of a Dual Thermoresponsive Supramolecular Pseudo-Block Copolymer, Macromolecules, 2011, 44, 1182 – 1193.
  55. Loh XJ, Zhang ZX, Mya KY, Wu YL, He CB, Li J*, Efficient gene delivery with paclitaxel-loaded DNA-hybrid polyplexes based on cationic polyhedral oligomeric silsesquioxanes, Journal of Materials Chemistry, 2010, 20, 10634 – 10642
  56. Li D, Ping Y, Xu F, Yu H, Pan H, Huang H, Wang Q, Tang G*, Li J*, Construction of a star-shaped copolymer as a vector for FGF receptor-mediated gene delivery in vitro and in vivo, Biomacromolecules, 2010, 11, 2221 – 2229.
  57. Li J*, Self-assembled supramolecular hydrogels based on polymer – cyclodextrin inclusion complexes for drug delivery,NPG Asia Materials,2010,2(3), 112 – 118.
  58. Bao H, Li L*, Gan LH, Ping Y,Li J, Ravi P, Thermo- and pH-responsive Association Behavior of Dual Hydrophilic Graft Chitosan Terpolymer Synthesized via ATRP and Click Chemistry,Macromolecules,2010,43, 5679 – 5687.
  59. Liu KL, Choo ESG ,Wong SY, Li X, He CB, Wang J,Li J* , Designing Poly[(R)-3-hydroxybutyrate]-Based Polyurethane Block Copolymers for Electrospun Nanofiber Scaffolds with Improved Mechanical Properties and Enhanced Mineralization Capability,The Journal of Physical Chemistry B,2010,114, 7489 – 7498 .
  60. Liu KL, Zhu JL ,Li J*, Elucidating rheological property enhancements in supramolecular hydrogels of short poly[(R,S)-3-hydroxybutyrate]-based amphiphilic triblock copolymer and a-cyclodextrin for injectable hydrogel applications,Soft Matter,2010,6, 2300 – 2311.
  61. Li M, Li G ,Li J, Neoh KG, Kang ET*, Self-assembly of pH Responsive and Fluorescent Comb like Amphiphilic Copolymers in Aqueous Media,Polymer,2010,51, 3377 – 3386.
  62. She Z, Antipina MN ,Li J*, Sukhorukov GB, Mechanism of Protein Release from Polyelectrolyte Multilayer Microcapsules,Biomacromolecules,2010,11, 1241 – 1247.
  63. Loh XJ, Peh P , Liao S, Sng C,Li J*, Controlled drug release from biodegradable thermoresponsive physical hydrogel nanofibers,Journal of Controlled Release,2010,143, 175 – 182.
  64. Dan C, Ping Y, Tang GP*,Li J*, Polyethyleneimine-grafted poly(N-3-hydroxypropyl)-aspartamide as a biodegradable gene vector for efficient gene transfection ,Soft Matter,2010,6, 955 – 964.
  65. Huang HL, Yu H, Tang GP*, Wang QQ,Li J*, Low molecular weight polyethylenimine cross-linked by 2-hydroxypropyl-γ-cyclodextrin coupled to peptide targeting HER2 as a gene delivery vector ,Biomaterials,2010,31, 1830 – 1838.
  66. Zhang Y, Yuwono AH, Wang J*,Li J, Enhanced Photocatalysis by Doping Cerium into Mesoporous Titania Thin Films,The Journal of Physical Chemistry C,2009,113, 21406 – 21412.
  67. Zhang XX, Zeng KY,Li J, Zhang YW*, Instability pathways of hydrogel microlenses under concentrated loadings,Journal of Applied Physics,2009,106, 023536.
  68. Loh XJ, Goh SH,Li J*, Biodegradable Thermogelling Poly[(R)-3-hydroxybutyrate]-Based Block Copolymers: Micellization, Gelation, and Cytotoxicity and Cell Culture Studies,The Journal of Physical Chemistry B,2009,113, 11822 – 11830.
  69. Xu FJ*, Ping Y, Ma J, Tang GP, Yang WT*,Li J, Kang ET, and Neoh KG, Comb-Shaped Copolymers Composed of Hydroxypropyl Cellulose Backbones and Cationic Poly((2-dimethyl amino)ethyl methacrylate) Side Chains for Gene Delivery,Bioconjugate Chemistry,2009,20, 1449 – 1458.
  70. Yang C, Ni X,Li J*, Synthesis of polypseudorotaxanes and polyrotaxanes with multiple a- and g-cyclodextrins co-threaded over poly[(ethylene oxide)-ran-(propylene oxide)],Polymer,2009,50, 4496 – 4504.
  71. Loh XJ, Gong J, Sakuragi M, Kitajima T, Liu M,Li J, Ito Y*, Surface coating with a thermoresponsive copolymer for the culture and nonenzymatic recovery of mouse embryonic stem cells,Macromolecular Bioscience,2009,9, 1069 – 1079.
  72. Loh XJ, Cheong WCD,Li J, Ito Y*, Novel poly(N-isopropylacrylamide)-poly[(R)-3-hydroxybutyrate]-poly(N-isopropylacrylamide) triblock copolymer surface as a culture substrate for human mesenchymal stem cells,Soft Matter,2009,5, 2937 – 2946.
  73. Zhang Y, Hong SC, Herman YA,Li J, Wang J*, Formation and Evolution of Body-Centered Orthorhombic Mesophase in TiO2 Thin Films.Journal of the American Ceramics Society,2009,92, 1317 – 1321.
  74. Li J*, Cyclodextrin Inclusion Polymers Forming Hydrogels (Invited Review).Advances in Polymer Science,2009,222, 79 – 112.
  75. Yang C, Yang J, Ni X,Li J*, Novel Supramolecular Block Copolymer: A Polyrotaxane Consisting of Many Threaded alpha- and gamma-Cyclodextrins with an ABA Triblock Architecture ,Macromolecules,2009,42, 3856 – 3859. (Highlighted on issuecover page)
  76. Yang C, Wang X, Li H, Tan E, Lim CT,Li J*, Cationic Polyrotaxanes as Gene Carriers: Physicochemical Properties and Real-time Observation of DNA Complexation, and Gene Transfection in Cancer Cells ,The Journal of Physical Chemistry B,2009,113, 7903 – 7911.
  77. Wu YL,Li J*, Synthesis of Supramolecular Nanocapsules Based on Threading of Multiple Cyclodextrins over Polymer on Gold Nanoparticles,Angewandte Chemie International Edition,2009,48, 3842 – 3845.
  78. Yang C, Ni X,Li J*, New Thermogelling Copolymers Composed of Heptakis-(2,6-di-O-methyl)-beta-cyclodextrin, Poly(propylene glycol), and Poly(ethylene glycol),Journal of Materials Chemistry,2009,19, 3755 – 3763.
  79. Li X, Liu KL, Wang M, Wong SY, Tjiua WC, He CB, Goh SH,Li J*, Improving hydrophilicity, mechanical properties, and biocompatibility of poly[(R)-3-hydroxybutyrate-co-(R)-3-hydroxyvalerate] through blending with poly[(R)-3-hydroxybutyrate]-alt-poly(ethylene oxide),Acta Biomaterialia,2009,5, 2002 – 2012.
  80. Yang C, Ni X,Li J*, Synthesis of Polyrotaxanes Consisting of Multiple alpha-Cyclodextrin Rings Threaded on Reverse Pluronic PPO-PEO-PPO Triblock Copolymers Based on Block-Selected Inclusion Complexation,European Polymer Journal,2009,45, 1570 – 1579.
  81. Yang C, Wang X, Li H, Ding JL, Wang DY,Li J*, A supramolecular gene carrier composed of multiple cationic a -cyclodextrins threaded on a PPO-PEO-PPO triblock polymer,Polymer,2009,50, 1378 – 1388.
  82. Xu FJ*, Zhang ZX, Ping Y,Li J, Kang ET, Neoh KG, Star-Shaped Cationic Polymers by Atom Transfer Radical Polymerization from b-Cyclodextrin Cores for Non-Viral Gene Delivery,Biomacromolecules,2009,10, 285 – 293.
  83. Yang C,Li J*, Thermo-Responsive Behavior of Cationic Polyrotaxane Composed of Multiple Pentaethylenehexamine-Grafted a -Cyclodextrins Threaded on Poly(propylene oxide)-Poly(ethylene oxide)-Poly(propylene oxide) Triblock Copolymer.The Journal of Physical Chemistry B,2009,113, 682 – 690.
  84. Loh XJ, Zhang ZX, Wu YL, Lee TS,Li J*, Synthesis of Novel Biodegradable Thermoresponsive Triblock Copolymers Based on Poly[(R)-3-hydroxybutyrate] and Poly(N-isopropylacrylamide) and Their Formation of Thermoresponsive Micelles.Macromolecules,2009,42, 194 – 202.
  85. Yang C, Li H, Wang X,Li J*, Cationic supramolecules consisting of oligoethylenimine-grafted a -cyclodextrins threaded on poly(ethylene oxide) for gene delivery.Journal Biomedical Materials Research Part A,2009,89A, 13 – 23.
  86. Ni XP, Cheng A ,Li J*, Supramolecular hydrogels based on self-assembly between PEO-PPO-PEO triblock copolymers and a-cyclodextrin.Journal Biomedical Materials Research Part A,2009,88A, 1031 – 1036.
  87. Loh XJ, Wu Y, Seow WTJ, Norimzan MNI, Zhang ZX, Xu FJ, Kang ET, Neoh KG,Li J*, Micellization and phase transition behavior of thermosensitive poly(N-isopropylacrylamide)-poly(epslon-caprolactone)-poly(N-isopropylacrylamide) triblock copolymers.Polymer,2008,49, 5084-5094.
  88. Zhang Y, Cooi C, Yuwono AH, Wang J*,Li J, Effect of neodymium doping on the structure and optical properties of mesoporous TiO2 thin films.Synthesis and Reactivity in Inorganic Metal-Organic and Nano-Metal Chemistry,2008,38,312-317.
  89. Zhang Y, Yuwono AH,Li J, Wang J*, Highly dispersed gold nanoparticles assembled in mesoporous titania films of cubic configuration.Microporous and Mesoporous Materials,2008,110,242-249.
  90. Xu FJ, Li HZ,Li J, Teo YHE, Zhu CX, Kang ET*, Neoh KG, Spatially well-defined binary brushes of poly(ethylene glycol)s for micropatterning of active proteins on anti-fouling surfaces,Biosensors and Bioelectronics,2008, 24, 773-780.
  91. Xu FJ,Li J, Su F, Zhao XS, Kang ET*, Neoh KG, Water-Dispersible Carbon Nanotubes for Aqueous Surface-Initiated Atom Transfer Radical Polymerization,Journal of Nanoscience and Nanotechnology,2008,8, 5858-5863.
  92. Li X,Li J*, Supramolecular hydrogels based on inclusion complexation between poly(ethylene oxide)-b-poly(e-caprolactone) diblock copolymer and a -cyclodextrin and their controlled release property.Journal Biomedical Materials Research Part A,2008,86A, 1055-1061.
  93. Zhang ZX, Liu X, Xu FJ, Loh XJ, Kang ET, Neoh KG,Li J*, Pseudo-Block Copolymer Based on Star-Shaped Poly(N-isopropylacrylamide) with a beta-Cyclodextrin Core and Guest-Bearing PEG: Controlling Thermoresponsivity through Supramolecular Self-Assembly.Macromolecules,2008,41,5967-5970.
  94. Liu KL, Goh SH,Li J*, Threading α-Cyclodextrin through Poly[(R,S)-3-hydroxybutyrate] in Poly[(R,S)-3-hydroxybutyrate]-Poly(ethylene glycol)-Poly[(R,S)-3-hydroxybutyrate] Triblock Copolymers: Formation of Block-Selected Polypseudorotaxanes .Macromolecules,2008,41,6027-6034.
  95. Li J*, Loh XJ, Cyclodextrin-based supramolecular architectures: syntheses, structures, and applications for drug and gene delivery (Invited Review).Advanced Drug Delivery Reviews,2008,60, 1000 – 1017. (Highlighted on issuecover page)
  96. Loh XJ, Sng C,Li J*, Synthesis and water-swelling of thermo-responsive poly(ester urethane)s containing polycaprolactone, poly(ethylene glycol) and poly(propylene glycol).Biomaterials,2008,29,3185 – 3194.
  97. Xu FJ, Li HZ,Li J, Zhang ZX, Kang ET*, Neoh KG, Pentablock copolymers of poly(ethylene glycol), poly((2-dimethyl amino)ethyl methacrylate) and poly(2-hydroxyethyl methacrylate) from consecutive atom transfer radical polymerizations for non-viral gene delivery.Biomaterials,2008,29,3023 – 3033.
  98. Loh XJ, Tan YX, Li Z, Teo LS, Goh SH,Li J*, Biodegradable thermogelling poly(ester urethane)s consisting of poly(lactic acid) – Thermodynamics of micellization and hydrolytic degradation.Biomaterials,2008,29(14), 2164 – 2172.
  99. Liu KL, Goh SH,Li J*, Controlled synthesis and characterizations of amphiphilic poly[(R,S )-3-hydroxybutyrate]-poly(ethylene glycol)-poly[(R,S )-3-hydroxybutyrate] triblock copolymers.Polymer,2008,49, 732 – 741.
  100. Xu F,Li J, Yuan SJ, Zhang ZX, Kang ET,* Neoh KG, Thermo-Responsive Porous Membranes of Controllable Porous Morphology from Triblock Copolymers of Polycaprolactone and Poly(N-isopropylacrylamide) Prepared by Atom Transfer Radical Polymerization.Biomacromolecules,2008,9, 331 – 339.
  101. Hui JH*, Chan SW,Li J, Goh JCH, Li L, Ren XF, Lee EH, Intra-articular delivery of chondroitin sulfate for the treatment of joint defects in rabbit model.Journal of Molecular Histology,2007, 38, 483 – 489.
  102. Yang C, Wang X, Li HZ, Goh SH,Li J*, Synthesis and characterization of polyrotaxanes consisting of cationic alpha-cyclodextrin threaded on poly[(ethylene oxide)-ran-(propylene oxide)] as gene carriers.Biomacromolecules,2007,8(11), 3365 – 3374.
  103. Xu F, Zhao JP, Kang ET*, Neoh KG,Li J, Functionalization of Nylon Membranes via Surface initiated Atom Transfer Radical Polymerization.Langmuir,2007,23, 8585-8592.
  104. Loh XJ,Li J*, Biodegradable thermosensitive copolymer hydrogels for drug delivery.Expert Opinion on Therapeutic Patents,2007,17(8), 965-977.
  105. Loh XJ, Goh SH,Li J*, Hydrolytic degradation and protein release studies of thermogelling polyurethane copolymers consisting of poly[(R)-3-hydroxybutyrate], poly(ethylene glycol), and poly(propylene glycol).Biomaterial,2007,28, 4113-4123.
  106. Yang C, Li H, Goh SH,Li J*, Cationic star polymers consisting of alpha-cyclodextrin core and oligoethylenimine arms as nonviral gene delivery vectors.Biomaterials,2007,28, 3245 – 3254.
  107. Loh XJ, Wang X, Li H, Li X,Li J*, Compositional and cytotoxicity studies of biodegradable poly(ester urethane)s consisting of poly[(R)-3-hydroxybutyrate] and poly(ethylene glycol).Materials Science & Engineering C , Biomimetic and Supramolecular Systems,2007,27(2), 267 – 273. (March 2007)
  108. Chao GT, Fan LY, Jia WJ, Qian Z Y,* Gu YC, Liu CB, Ni XP,Li J, Deng HX, Gong CY, Gou ML, Lei K, Huang AL, Huang CH, Yang JL, Kan B, Tu MJ, Synthesis, characterization and hydrolytic degradation of degradable poly(butylene terephthalate)/poly(ethylene glycol) (PBT/PEG) copolymers.Journal of Materials Science – Materials in Medicine,2007,18, 449 – 455.
  109. Loh XJ, Goh SH,Li J*, New Biodegradable Thermogelling Copolymers Having Very Low Gelation Concentrations.Biomacromolecules,2007,8(2), 585 – 593.
  110. Li X, Liu KL,Li J*, Tan PS, Chan LM, Lim CT, Goh SH, Synthesis, Characterization, and Morphology Studies of Biodegradable Amphiphilic Poly[(R)-3-hydroxybutyrate]-alt-Poly(ethylene glycol) Multiblock Copolymers.Biomacromolecules,2006,7(11), 3112 – 3119.
  111. Li J*, Yang C, Li H, Wang X, Goh SH, Ding JL, Wang DY, Leong KW, Cationic Supramolecules Composed of Multiple Oligoethylenimine-Grafted beta-Cyclodextrins Threaded on a Polymer Chain for Efficient Gene Delivery.Advanced Materials,2006,18(22), 2969 – 2974.
  112. Zhang Y, Wang J,*Li J, Mesophase configurations and optical properties of mesoporous TiO 2 thin films,Journal of Electroceramics,2006, 16(4), 499 – 502.
  113. Zhang Y,Li J, Wang J ,* Substrate-Assisted Crystallization and Photocatalytic Properties of Mesoporous TiO 2 Thin Films .Chemistry of Materials,2006,18(12), 2917 – 2923.
  114. Li J*, Li X, Ni X, Wang X, Li H, Leong KW, Self-assembled supramolecular hydrogels formed by biodegradable PEO-PHB-PEO triblock copolymers and a -cyclodextrin for controlled drug delivery .Biomaterials,2006,27, 4132 – 4140.
  115. Palaniappan AL, Li X, Tay FEH,Li J, Su X,* Cyclodextrin functionalized mesoporous silica films on quartz crystal microbalance for enhanced gas sensing.Sensors and Actuators B, Chemical,2006,119 (1), 220 – 226.
  116. Zhang YZ,* Wang X, Feng Y,Li J, Lim CT, Ramakrishna S , Coaxial electrospinning of (fluorescein isothiocyanate-conjugated bovine serum albumin)-encapsulated poly( e -caprolactone) nanofibers for sustained release .Biomacromolecules,2006,7, 1049 – 1057.
  117. Jongpaiboonkit L, Zhou Z, Ni X, Wang YZ,Li J*, Self-association and micelle formation of biodegradable poly(ethylene glycol)-poly( l-lactic acid) amphiphilic diblock copolymers.Journal of Biomaterials Science, Polymer Edition,2006, 17, 747 – 763.
  118. Li X, Mya KY, Ni X, He C, Leong KW,Li J*, Dynamic and Static Light Scattering Studies on Self-Aggregation Behavior of Biodegradable Amphiphilic Poly(ethylene oxide)-Poly[(R)-3-hydroxybutyrate]-Poly(ethylene oxide) Triblock Copolymers in Aqueous Solution .Journal of Physical Chemistry B,2006,110 (12), 5920 – 5926.
  119. Loh XJ, Tan KK, Li X,Li J*, Thein vitrohydrolysis of poly(ester urethane)s consisting of poly[(r)-3-hydroxybutyrate] and poly(ethylene glycol).Biomaterials,2006,27, 1841 – 1850.
  120. Huang HX, Yang KK, Wang YZ,* Wang XL,Li J, Synthesis, Characterization and Thermal Properties of a Novel Pentaerythritol-initiated Star-shaped Poly(p-dioxanone).Journal of Polymer Science, Part A, Polymer Chemistry,2006,44 (3), 1245 – 1251.
  121. Zhou ZX, Wang XL, Wang YZ,* Yang KK, Chen SC, Wu G,Li J, Thermal properties and non-isothermal crystallization behavior of biodegradable poly(p-dioxanone)/poly(vinyl alcohol) blends.Polymer International,2006,55, 383 – 390.
  122. Liu CB, Qian ZY,* Gu YC, Fan LY,Li J, Chao GT, Jia WJ, Tu MJ, Synthesis, characterization, and thermal properties of biodegradable aliphatic copolyester based on e -caprolactone, adipic acid, and 1,6-hexanediol.Materials Letters,2006,60, 31 – 38.
  123. Liu CB, Gu YC, Qian ZY,* Fan LY,Li J, Chao GT, Tu MJ, Jia WJ, Hydrolytic degradation behavior of biodegradable polyetheresteramide-based polyurethane copolymers.Journal of Biomedical Materials Research Part A,2005,75A,465 – 471.
  124. Li X, Loh XJ, Wang K, He C,Li J*, Poly(ester urethane)s Consisting of Poly[(R)-3-hydroxybutyrate] and Poly(ethylene glycol) as Candidate Biomaterials: Characterization and Mechanical Property Study.Biomacromolecules,2005,6, 2740 – 2747.
  125. Li J*, Ni X, Li X, Tan NK, Lim CT, Ramakrishna S, Leong KW, Micellization Phenomena of Biodegradable Amphiphilic Triblock Copolymers Consisting of Poly( b -hydroxyalkanoic acid) and Poly(ethylene oxide).Langmui,2005,21, 8681 – 8685.
  126. Mya KY, Li X, Chen L, Ni XP,Li J, He CB ,* Core-Corona Structure of Cubic Silsesquioxane-Poly(ethylene oxide) in Aqueous Solution: Fluorescence, Light Scattering, and TEM Studies .The Journal of Physical Chemistry B,2005,109, 9455-9462.
  127. Zheng L, Wang YZ,* Yang KK, Wang XL, Chen SC,Li J, Effect of PEG on the Crystallization of PPDO/PEG Blends.European Polymer Journal,2005,41, 1243 – 1250.
  128. Zhang YH, Wang XL, Wang YZ,* Yang KK,Li J, A Novel Biodegradable Polyesters from Chain-Extension of Poly(p-dioxane) with Poly(butylene succinate).Polymer Degradation and Stability,2005,88, 294 – 299.
  129. Li J *, Li X, Ni X, Wang X, Li H, Zhou Z, Injectable Supramolecular Hydrogels Self-Assembled by Polymers and Cyclodextrins for Controlled Drug Delivery.Key Engineering Materials,2005,288/289, 117 – 120.
  130. Wang Y, Liu CB, Fan LY, Sheng Y, Mao J, Chao G,Li J, Tu MJ, Qian ZY ,* Synthesis of biodegradable poly(butylene terephthalate)/poly(ethylene glycol) (PBT/PEG) multiblock copolymers and preparation of indirubin loaded microspheres.Polymer Bulletin,2005,53, 147 – 154.
  131. Bao XY, Zhao XS,* Li X,Li J, Pore Structure Characterization of Large-Pore Periodic Mesoporous Oganosilicas Synthesized with Varing SiO 2/Template Ratios.Applied Surface Science,2004,237, 380 – 386.
  132. Li X,Li J*, Leong KW, Role of Intermolecular Interaction between Hydrophobic Blocks in Block-Selected Inclusion Complexation of Amphiphilic Poly(ethylene oxide)-Poly[(R)-3-hydroxybutyrate]-Poly(ethylene oxide) Triblock Copolymers with Cyclodextrins.Polymer,2004,45, 6845 – 6851.
  133. . Bao XY, Zhao XS,* Li X, Chia PA,Li J, A Novel Route toward the Synthesis of High-Quality Large-Pore Periodic Mesoporous Organosilicas.Journal of Physical Chemistry B,2004,108, 4684 – 4689.
  134. Quek CH,Li J*, Sun T, Chan MLH, Mao HQ, Gan LM, Leong KW, Yu H, Photo-Crosslinkable Microcapsules Formed by Polyelectrolyte Copolymer and Modified Collagen for Rat Hepatocyte Encapsulation.Biomaterials,2004,25, 3531 – 3540.
  135. Li J*,Chen B, Wang X, Goh SH, Inclusion Complexes Formed by Biodegradable Poly( e -caprolactone)-Poly(tetrahydrofuran)-Poly( e -caprolactone) Triblock Copolymer and Cyclodextrins.Polymer, 2004 ,45, 1777 – 17
  136. Huang J, Li X, Lin T, He C,* Mya KY, Xiao Y,Li J*,Inclusion complex formation between a , g -cyclodextrins and organic-inorganic star-shaped poly(ethylene glycol) from octafunctional silsesquioxane core.Journal Polymer Science, Part B, Polymer Physics,2004,42, 1173 – 1180.
  137. Li J*, Li X, Ni X, Leong KW, Synthesis and Characterization of New Biodegradable Amphiphilic Poly(ethylene oxide)-b-Poly[(R)-3-hydroxybutyrate]-b-Poly(ethylene oxide) Triblock Copolymers.Macromolecules,2003, 36, 2661 – 2667.
  138. Li J*, Ni X, Zhou Z, Leong KW, Preparation and Characterization of Polypseudorotaxanes Based on Block-Selected Inclusion Complexation between Poly(propylene oxide)-Poly(ethylene oxide)-Poly(propylene oxide) Triblock Copolymers and a -Cyclodextrin.Journal of the American Chemical Society,2003,125,1788 – 1795.
  139. Li J*, Ni X, Leong KW, Injectable Drug-Delivery Systems Based on Supramolecular Hydrogels Formed by Poly(ethylene oxide)s and Cyclodextrin.Journal of Biomedical Materials Research Part A,2003,65A,196 – 202.
  140. Li X,Li J*, Leong KW, Preparation and Characterization of Inclusion Complexes of Biodegradable Amphiphilic Poly(ethylene oxide)-Poly[(R)-3-hydroxybutyrate]-Poly(ethylene oxide) Triblock Copolymers with Cyclodextrins.Macromolecules,2003,36,1209 – 1214.
  141. Li J*, Ni X, Leong KW, Block-Selected Molecular Recognition and Formation of Polypseudorotaxanes between Poly(propylene oxide)-Poly(ethylene oxide)-Poly(propylene oxide) Triblock Copolymers and a -Cyclodextrin.Angewante Chemie International Edition,2003,42, 69 – 72.
  142. Li J*, Toh KC, Formation of Inclusion Complexes between Dimers of(R)-3-Hydroxybutanoic Acid and Cyclodextrin: Thermodynamic Study of the Complexation and Conformational Analysis of the Complexed Dimers .Journal of the Chemical Society, Perkin Transaction 2,2002, 35 – 40.
  143. Li J*, Li X, Toh KC, Ni X, Zhou Z, Leong KW, Inclusion Complexation and Formation of Polypseudorotaxanes between Poly[(ethylene oxide)-ran-(propylene oxide)] and Cyclodextrins.Macromolecules,2001,34, 8829 – 8831.
  144. Li J*, Li X, Zhou Z, Ni X, Leong KW, Formation of Supramolecular Hydrogels Induced by Inclusion Complexation between Pluronics and Cyclodextrin.Macromolecules,2001,34,7236 – 7237.
  145. Chia SM, Leong KW,Li J, Xu X, Zeng K, Er PN, Gao S, Yu H*, Hepatocyte Encapsulation for Enhanced Cellular Functions.Tissue Engingeering,2000,6,481 – 495.
  146. Li J, Uzawa J, Doi Y, NMR Spectroscopic Studies on Complex Formation between Dimeric (R)-3-Hydroxybutanoic Acid and b -Cyclodextrin.Bulletin of the Chemical Society of Japan,1998,71, 1953 – 1957.
  147. Li J, Uzawa J, Doi Y*, Conformational Analysis of Oligomers of (R)-3-Hydroxybutanoic Acid in Solutions by Proton NMR Spectroscopy.Bulletin of the Chemical Society of Japan,1998,71, 1683 – 1689.
  148. Harada A*,Li J, Kamachi M, Kitagawa Y, Katsube Y, Structures of Polyrotaxane Models.Carbohydrate Research,1997, 305, 127 – 129.
  149. Harada A*,Li J, Kamachi M*, Non-ionic [2]Rotaxanes Containing Methylated a -Cyclodextrin.Chemical Communications,1997, 1413 – 1414.
  150. .Li J, Uzawa J, Doi Y*, Conformational Behavior of Methyl (3R)-3- {[(3’R)-3′-Hydroxybutanoyl]oxy}butanoate in Solutions: Effect of Intramolecular Hydrogen Bond.Bulletin of the Chemical Society of Japan,1997, 70, 1887 – 1893.
  151. Harada A*,Li J, Kamachi M*, Molecular Recognition: Preparation of Polyrotaxane and Tubular Polymer from Cyclodextrin.Polymers for Advanced Technologies,1997, 8, 241-249.
  152. Harada A*, Okada M,Li J, Kamachi M*, Preparation and Characterization of Inclusion Complexes of Poly(propylene glycol) with Cyclodextrins.Macromolecules,1995,28, 8406 – 8411.
  153. Harada A*,Li J, Kamachi M*, Preparation of Tubular Polymers from Cyclodextrin.Journal ofMacromolecular Science Part A, Pure and Applied Chemistry,1995,A32, 813 – 819.
  154. Harada A*,Li J, Kamachi M*, Double-Stranded Inclusion Complexes of Cyclodextrin threaded on Poly(ethylene glycol).Nature,1994,370, 126 – 128.
  155. Li J, Harada A*, Kamachi M*, Formation of Inclusion Complexes of Oligoethylene and Its Derivatives with a -Cyclodextrin.Bulletin of the Chemical Society of Japan,1994, 67, 2808 – 2818.
  156. Harada A*,Li J, Kamachi M*, Formation of Inclusion Complexes of Monodisperse Oligo(ethylene glycol)s with a -Cyclodextrin.Macromolecules,1994, 27,4538 – 4543.
  157. Li J, Harada A*, Kamachi M*, Sol-Gel Transition during Inclusion Complex Formation between a -Cyclodextrin and High Molecular Weight Poly(ethylene glycol)s in Aqueous Solution.Polymer Journal,1994, 26, 1019 – 1026.
  158. Harada A*,Li J, Kamachi M*, Preparation and Characterization of a Polyrotaxane Consisting of Monodisperse Poly(ethylene glycol) and a -Cyclodextrins.Journal of the American Chemical Society,1994, 116, 3192 – 3196.
  159. Harada A*,Li J, Nakamitsu T, Kamachi M*, Preparation and Characterization of Polyrotaxanes Containing Many Threaded a -Cyclodextrins.Journal of Organic Chemistry,1993, 58, 7524 – 7528.
  160. Harada A*,Li J, Kamachi M*, Synthesis of a Tubular Polymer from Threaded Cyclodextrins.Nature,1993,364, 516 – 518.
  161. Harada A*,Li J, Kamachi M*, Preparation and Properties of Inclusion Complexes of Poly(ethylene glycol) with a -Cyclodextrin.Macromolecules,1993, 26, 5698 – 5703.
  162. Harada A*,Li J, Suzuki S, Kamachi M*, Complex Formation between Polyisobutylene and Cyclodextrins : Inversion of Chain-Length Selectivity between b -Cyclodextrin and g -Cyclodextrin.Macromolecules,1993, 26, 5267 – 5268.
  163. Harada A*,Li J, Kamachi M*, Macromolecular Recognition: Formation of Inclusion Complexes of Polymers with Cyclodextrins.Proceedings of the Japan Academy,Series B, Physical and Biological Sciences,1993,69, 39 – 44.
  164. Harada A*,Li J, Kamachi M*, Complex Formation between Poly(methyl vinyl ether) and g -Cyclodextrin.Chemistry Letters,1993, 237 – 240.
  165. Harada A*,Li J, Kamachi M*, The Molecular Necklace: A Rotaxane Containing Many Threaded a -Cyclodextrins.Nature,1992,356, 325 – 327.

Staff Details

Contact Number

6516 7273

Email Address

bielj@nus.edu.sg

Location

E1-05-28

Website

Google Scholar