ISEM Seminar Series
“Deep Conditional Generative Learning for Risk-averse Individualized Treatment Rules” by Wen Su Assistant Professor, Department of Biostatistics City University of Hong Kong |
27 December 2024 (Friday), 5pm – 6pm Venue: E1-07-21/22 - ISEM Executive Classroom |
ABSTRACT
Personalized treatment regimes tailored to account for individual characteristics have revolutionized the healthcare industry, offering substantial potential to maximize treatment benefits and enhance patient survival. However, the current methods for estimating individualized treatment rules in multi-treatment settings have limitations due to the lack of theoretical foundations and challenges related to model misspecification. To address these issues, we propose a novel generative learning approach called {CG-Learning}, that utilizes Wasserstein GAN to estimate the optimal decision rule that maximizes the value function for multi-treatment regimes. We derive important theoretical results of the proposed estimator including the nonasympototic error bound for the estimated optimal value and an upper bound for the probability that the estimated decision rule is not the optimal treatment option. To evaluate performance of {CG-Learning}, we conduct extensive simulation studies under various scenarios, with comparisons to existing approaches. Furthermore, we apply the proposed method to a dataset from the AIDS Clinical Trials Group for illustration. |
Dr. Wen Su is an Assistant Professor at the Department of Biostatistics in the City University of Hong Kong. She received her PhD in Statistics from the University of Hong Kong. She earned her Bachelor of Science in Industrial Engineering from the University of Toronto and Master of Science in Biostatistics from Columbia University. Dr. Su’s research in survival analysis has been focused on developing new statistical methods using deep learning techniques for analyzing complex time-to-event data, particularly in the context of medical research. |