Optical bioimaging: bioimage informatics, and Artificial Intelligence.
Force generation, force transmission, and force sensing at the molecular scale in biological systems.
Mechanobiology of Cell-cell and cell-matrix interactions
Research Projects
Development and application of 3-dimensional interferometric super-resolution microscopy
Nanoscale architecture of cell-matrix adhesion complexes
Crosstalk of cell adhesions and mitotic cell division
Mechanobiology of Aging Cells
Selected Awards & Honours
Singapore NRF Fellowship (2011-2016)
HHMI Predoctoral Fellowship (2001-2006)
Stanford Graduate Fellowship (2001-2004)
Phi Beta Kappa (2001)
Membership in Scientific/Professional Organization
American Society for Cell Biology
Biophysical Society
Selected Journal Publications
Pakorn Kanchanawong*, David Calderwood*, “Organisation, dynamics and mechanoregulation of integrin-mediated cell–ECM adhesions” Nature Reviews Molecular and Cellular Biology 24.2 (2023): 142-161 doi.org/10.1038/s41580-022-00531-5.
Yinan Wang, Samuel Barnett, Shimin Le, Zhenhuan Guo, Xueying Zhong, Pakorn Kanchanawong*, Jie Yan*. “Label-free single-molecule quantification of rapamycin-induced FKBP-FRB dimerization for Direct Control of Cellular Mechanotransduction” Nano Letters 19(10) 7514-7525 (2020).
Shumin Xia, Bena Lim, Yilin Wang, Zhen Zhang, Shan Zhang, Chwee Teck Lim, Evelyn K. F. Yim, Pakorn Kanchanawong, “Nanoscale Architecture of the Cortical Actin Cytoskeletons in Embryonic Stem Cells”, Cell Reports 28(5), P1251-1267.E7, (2019).
Nisha Bte Mohd Rafiq, Yukako Nishimura, Sergey V Plotnikov, Visalatchi Thiagarajan, Zhen Zhang, Shidong Shi, Meenubharathi Natarajan, Virgile Viasnoff, Pakorn Kanchanawong*, Gareth Jones*, and Alexander D. Bershadsky* “A mechano-signalling network linking microtubules, myosin-IIA filaments and integrin-based adhesions” Nature Materials, 18: 638-649 (2019).
Cristina Bertocchi, Yilin Wang, Andrea Ravasio, Yusuke Hara, Yao Wu, Talgat Sailov, Michelle A. Baird, Michael W. Davidson, Ronen Zaidel-Bar, Yusuke Toyama, Benoit Ladoux, Rene-Marc Mege, and Pakorn Kanchanawong. “Nanoscale architecture of cadherin-based cell adhesions” Nature Cell Biology. Nature Cell Biology 2017, 19 (1), 28-37.
J. Liu, Y. Wang, W. I. Goh, H. Goh, M. A. Baird, S. Ruehland, S. Teo, N. Bate, D. R. Critchley, M. W. Davidson, P. Kanchanawong, “Talin determines the nanoscale architecture of focal adhesions” PNAS, 112 (35), E4864-E4873.
Y. Wu, P. Kanchanawong, R. Zaidel-Bar, “Actin-Delimited Adhesion-Independent Clustering of E-Cadherin Forms the Nanoscale Building Blocks of Adherens Junctions” Developmental Cell. (2015) 32 (2), 139-154.
P. Kanchanawong, G. Shtengel, A. Pasapera-Limon, E. Ramko, M.W. Davidson, H.F. Hess, C. M. Waterman. “Nanoscale Architecutre of Integrin-based Adhesions”, Nature, 468(7323): 580-4, 2010.
G. Shtengel, J. A. Galbraith, C. G. Galbraith, J. Lippincott-Schwartz, J. M. Gillette, S. Manley, R. Sougrat, C. M. Waterman, P. Kanchanawong, M. W. Davidson, R. D. Fetter and H. F. Hess. “Interferometric fluorescent super-resolution microscopy resolves 3D cellular ultrastructure”, PNAS, 106 (9), 3125-3130, 2009.
