Changhuei Yang is a Professor in the Department of Electrical and Computer Engineering and the Department of Biomedical Engineering at the National University of Singapore. His return to Singapore is supported in part by the NRF RSSS program. Yang previously served on the faculty of the California Institute of Technology from 2005 to 2026, holding the Thomas G. Myers Professorship of Electrical Engineering, Bioengineering, and Medical Engineering from 2015, and culminating in his appointment as the Executive Officer (department head) of the Caltech Electrical Engineering department.
A pioneer of both computational microscopy and wavefront shaping research, Yang’s work focuses on computational imaging, the use of deep neural networks for image analysis, and time-reversal wavefront shaping for deep tissue imaging. Over the past two decades, his research team has developed numerous novel biomedical imaging technologies, including time-reversal optical methods for focusing light deep into tissue, lensless microscopy, ePetri, Fourier Ptychography, non-invasive brain activity monitoring methods, and AI oriented microscopy implementations. He has also worked with major companies, including Bio-Rad, Amgen, and Micron-Aptina, to develop solutions to their technological challenges. His work has been cited more than 34,000 times and has an h-index of 86 (Google Scholar as of August 2026). He is ranked among the top 1% of scientists worldwide (Stanford/Elsevier, 2025).
Yang holds over 90 patents, 52 of which have been licensed to a range of startups and major companies, including Amgen, Bio-Rad Laboratories, Leica Microsystems, HI (operating as Kernel), Cellavision, ePetri, Mango Inc., Visualyze Technologies, and 5D Optics. He is the founder of Clearbridge Biophotonics (acquired by Cellavision) and a co-founder of Mango Inc., which is set to launch a bioburden imaging analyzer in 2026; both companies are built on core IPs developed by his team. He is also responsible for core IPs underlying Bioptigen (acquired by Leica Microsystems) and HI (operating as Kernel).
Yang is the recipient of the NSF CAREER Award, the Coulter Foundation Early Career Phase I and II Awards, and the NIH Director’s New Innovator Award. He is a Coulter Fellow, an AIMBE Fellow, an Optica Fellow, and a SPIE Fellow, and was inducted as a Fellow of the National Academy of Inventors in 2020 in recognition of his extensive and impactful work.